PMID: 9173922Apr 1, 1996Paper

Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat

Neurobiology of Disease
S KurodaB K Siesjö

Abstract

The present experiments were undertaken to explore the mechanisms of secondary brain damage in focal ischemia of long duration (2 h), followed by recirculation. Recirculation has previously been found to cause partial recovery and secondary deterioration of cellular bioenergetic state, the subsequent damage being ameliorated by a free radical spin trap, alpha-phenyl-N-tert-butyl nitrone (PBN), even when the drug was given 1 (or 3) h after the start of recirculation. Our objective was to assess whether the secondary deterioration of the cellular bioenergetic state is due to mitochondrial dysfunction and to study whether PBN acts by preventing secondary damage to mitochondria. Focal and perifocal ("penumbral") tissues were sampled after 2 h of ischemia and after 1, 2, and 4 h of recirculation; at the latter two times, vehicle- and PBN-injected animals were studied, PBN being given after 1 h of recirculation. Homogenates were prepared, and stimulated (+ADP), nonstimulated (-ADP), and uncoupled respiratory rates were measured polarographically. The results were similar in focus and penumbra, albeit more pronounced in the focus. Ischemia was associated with a decrease in ADP-stimulated and uncoupled respiration rates, with a marked ...Continue Reading

Citations

Jan 1, 1997·Stroke; a Journal of Cerebral Circulation·G GidöB K Siesjö
Mar 14, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E GillandH Hagberg
Oct 3, 1999·Physiological Reviews·P Lipton
Oct 24, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L OlahM Hoehn
Apr 27, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A LewénL Hillered
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cecilia M P RodriguesClifford J Steer
Mar 21, 2003·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Akihito NakaiTsutomu Araki
Jul 21, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Takashi YokotaHiroyuki Tsutsui
Aug 26, 1999·Journal of Neurochemistry·M F Anderson, N R Sims
Jan 29, 2000·Microscopy Research and Technique·J WeiseM Bähr
Nov 5, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R TsuchidateB K Siesjö
Jan 9, 2001·The Journal of Obstetrics and Gynaecology Research·A NakaiT Araki
Sep 4, 1998·Pediatric Research·J D HanrahanD Azzopardi
Nov 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N MarklundL Hillered
Jul 5, 2007·The Journal of Biological Chemistry·Jin YuTatyana I Gudz
Apr 29, 2008·Journal of Neuroscience Research·Chun Yan ZhengXi Can Tang
Jan 28, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masaaki HokariYoshinobu Iwasaki
Jul 30, 2009·Journal of Neurotrauma·Lesley K GilmerStephen W Scheff
Jun 26, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mayumi YamatoHideo Utsumi
Apr 13, 2018·Stroke; a Journal of Cerebral Circulation·Anja KahlAlexander Galkin
Apr 10, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G FiskumM F Beal
Mar 16, 2007·Expert Opinion on Emerging Drugs·Paul A Lapchak, Dalia M Araujo
May 4, 2002·Stroke; a Journal of Cerebral Circulation·Hayrunnisa BolayTurgay Dalkara
Feb 28, 2009·Journal of Cardiovascular Pharmacology·Sergei A Novgorodov, Tatyana I Gudz
Jul 13, 2007·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Akihito Nakai
Oct 8, 2003·CNS Drug Reviews·Paul A Lapchak, Dalia M Araujo
Nov 5, 2003·Arquivos de neuro-psiquiatria·Sinésio Grace DuarteBenedicto Oscar Colli
May 2, 2013·Oxidative Medicine and Cellular Longevity·Zhanyang YuXiaoying Wang
Jun 7, 2019·Neuromolecular Medicine·Jared A SperlingPrasad V G Katakam
Apr 27, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L OlahM Hoehn
Mar 20, 1998·Stroke; a Journal of Cerebral Circulation·T Kristián, B K Siesjö

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.