Delayed treatment with human umbilical cord blood-derived stem cells attenuates diabetic renal injury

Transplantation Proceedings
Jehyun ParkH Ha

Abstract

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide. Excess accumulation of extracellular matrix and the epithelial-to-mesenchymal transition contribute to renal fibrosis, which is associated with DKD. The present study examined whether delayed treatment with human umbilical cord blood-derived stem cells (hUCB-SC) showed a therapeutic effect on DKD progression. Experimental diabetes was induced by intraperitoneal injection of streptozotocin (STZ; 50 mg/kg) into 6-week-old male Sprague-Dawley rats. Age-matched control rats received an equivalent volume of sodium citrate buffer alone. At 4 weeks after the STZ injection when diabetic renal injury had developed, hUCB-SC were administered (1 × 10(6) cells/rat) through the tail vein. Four weeks after administering the hUCB-SC, rats were sacrificed and we measured indices of DKD, including urinary protein excretion as well as fibronectin, α-smooth muscle actin (α-SMA), and E-cadherin mRNA, and protein expression. Diabetic rats developed significantly increased urinary protein excretion and renal hypertrophy compared to those in control rats. Renal expression of fibronectin and α-SMA mRNA, and protein were increased significantly in diabetic rats com...Continue Reading

References

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Citations

Oct 3, 2012·Diabetes Research and Clinical Practice·Jong Hee ParkHunjoo Ha
Mar 24, 2016·Current Diabetes Reports·Tomás P GriffinMatthew D Griffin
Jun 18, 2014·Frontiers in Endocrinology·Grace C DaveyTimothy O'Brien
Feb 16, 2019·Stem Cells International·Quan ZhuangYingzi Ming
Jan 7, 2017·Stem Cells International·Janaina PauliniÉrika B Rangel
Nov 23, 2020·Cell Death & Disease·Dongwei LiuZhangsuo Liu
Jan 31, 2015·Disease Models & Mechanisms·Diana A PapazovaMarianne C Verhaar
Jun 10, 2021·Stem Cells Translational Medicine·LaTonya J HicksonM Hassan Murad

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