Delayed treatment with rolipram protects against neuronal damage following global ischemia in rats

Neuroreport
F BlockM Schwarz

Abstract

In this study the effect of post-treatment with rolipram, an inhibitor of cAMP phosphodiesterase, on neuronal damage following global ischemia was evaluated. Global cerebral ischemia was induced in male Wistar rats by four-vessel occlusion for 20 minutes. Rolipram was administered 6 hours after onset of ischemia and thereafter the following 7 days daily once at a dose of 0.3 or 3.0 mg/kg intraperitoneally. Four weeks after ischemia the amount of intact neurons in the hippocampus and in the striatum was assessed following perfusion fixation. The ischemia-induced neuronal damage in the CA1 sector of the hippocampus and in the striatum was reduced by rolipram at either dose. The present results show that treatment with rolipram reduces ischemic neuronal damage at a therapeutic window of 6 hours.

References

Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S A Loddick, N J Rothwell

❮ Previous
Next ❯

Citations

Jun 1, 2005·Progress in Neurobiology·F BlockM Loos
May 26, 1999·Progress in Neurobiology·F Block
Jun 5, 2001·Neuroreport·F BlockM Schwarz
Jan 1, 2010·Anesthesia and Analgesia·Naoko OkayamaYuichi Kanmura
May 1, 2001·The European Journal of Neuroscience·A J Hampson, M Grimaldi
Jul 5, 2005·Expert Opinion on Investigational Drugs·H J Dyke, J G Montana
Sep 15, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hideo TsukadaTakeharu Kakiuchi
Oct 6, 2007·Experimental Neurology·Coleen M AtkinsW Dalton Dietrich
Apr 22, 2008·Neurobiology of Disease·Zena DeMarchFrancesca Romana Fusco
Apr 27, 2012·Journal of Neuroscience Research·C M AtkinsW D Dietrich
Jul 27, 1999·Current Opinion in Chemical Biology·A M Doherty
Jan 1, 2004·Nature Genetics·Benoît FunalotJean-Louis Mas
Aug 24, 2019·Frontiers in Cellular Neuroscience·Saef IzzyMichael J Whalen
Dec 20, 2020·The European Journal of Neuroscience·Jéssica M BonatoRúbia Maria Weffort de Oliveira
Jul 17, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Abid BhatMeena Kishore Sakharkar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.