PMID: 9298489Aug 1, 1997Paper

Deleted form of hepatocyte growth factor (dHGF) increases the number of platelets in rats with liver cirrhosis

Liver
H MasunagaK Higashio

Abstract

The effect of the deleted form of hepatocyte growth factor (dHGF) on thrombopoiesis was studied in rats. When normal rats were injected with dHGF (0.5 mg/kg i.v. twice a day), the number of platelets increased to about 1.5-fold the initial level. In addition, the treatment with dHGF (0.5 mg/kg i.v. twice daily) significantly increased the number of platelets in rats with liver cirrhosis induced by carbon tetrachloride and phenobarbital. When dHGF was given to rats at a dose of 0.05 or 0.5 mg/kg from the beginning of the induction of dimethylnitrosamine liver cirrhosis to day 28, dHGF dose-dependently ameliorated thrombocytopenia and completely prevented it at a dose of 0.5 mg/kg. These results indicate that dHGF may be applicable to the treatment of thrombocytopenia associated with liver cirrhosis.

References

Jul 16, 1990·Biochemical and Biophysical Research Communications·K HigashioT Morinaga
Jun 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hirohito TsubouchiY Muto
Sep 15, 1989·Biochemical and Biophysical Research Communications·K MiyazawaK Takahashi
Jul 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M Carr
Sep 1, 1986·Experimental Cell Research·E GohdaY Daikuhara
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L BoksH H Van Vliet
Dec 14, 1995·Biochemical and Biophysical Research Communications·M HinoN Tatsumi

Citations

Feb 28, 2002·Alimentary Pharmacology & Therapeutics·G MarinoD A Flockhart
Jan 30, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takashi KosoneMasatomo Mori

Related Concepts

Carbon Tetrachloride
Dimethylnitrosamine
Dose-Response Relationship, Drug
Liver
Liver Cirrhosis, Experimental
Platelet Count Measurement
Thrombotest
Spleen
Thrombocytopenia
Rats, Wistar

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