Deleterious actions of chronic ethanol treatment on the glycosylation of rat brain clusterin

Brain Research
E A HaleP Ghosh

Abstract

Clusterin is a N-glycosylated sialoglycoprotein present in rat brain cells. Clusterin, which elicits aggregation in a wide variety of cells, has been suggested to play an important role in synaptic remodeling through its cell adhesion property or lipid transport capacity in the brain. Sialic acid residues in clusterin may be responsible for its structural conformation, stability and functional ability. Maturation of clusterin is governed by the relative actions of sialyltransferases and sialidases that are present in brain microsomes, golgi bodies, cytosol and plasma membranes. We have earlier reported that chronic ethanol treatment in rats has a damaging effect on the hepatic glycosylation machinery. Others have reported increased hydrolysis of brain sialoconjugates in rats following chronic ethanol administration. Specificity of the effects of chronic ethanol treatment in the brain in relation to the glycosylation process, is still obscure. Therefore, in this investigation, we have studied the specific effects of chronic ethanol treatment on the glycosylation of rat brain clusterin and the causes that may lead to any possible defects in the glycosylation process. We have determined the effects of chronic ethanol treatment on ...Continue Reading

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Citations

Oct 2, 1998·Alcoholism, Clinical and Experimental Research·P GhoshE A Hale
Jul 9, 1999·Alcoholism, Clinical and Experimental Research·M PönniöP Sillanaukee
Jul 18, 2002·Critical Reviews in Clinical Laboratory Sciences·Minna L HannukselaMarkku J Savolainen
Nov 21, 2009·Drug and Alcohol Dependence·Melinda E LullKent E Vrana
Oct 31, 2008·Journal of Biochemical and Molecular Toxicology·Serkan DegirmenciGüngör Kanbak
Jan 11, 2005·Forensic Science International : Synergy·N IdizI Ilhan
Dec 4, 2012·The International Journal of Biochemistry & Cell Biology·Sang-Wook KangDong-Hou Kim

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