Abstract
This study examined the impact of prednisone (PDN) on cytomegalovirus (CMV) infection after allogeneic stem cell transplantation (allo-SCT) according to donor and recipient CMV serostatus. Seventy-five patients underwent allo-SCT from June 2010 to July 2012. The risk of CMV infection according to donor and recipient serostatus was defined as follows: high risk (HR; D-/R+), intermediate risk (IR; D+/R+ and D+/R-), and low risk (D-/R-). Forty-five patients (60%) developed CMV infection, and 46 patients (61%) received steroids (PDN ≥ 1 mg/kg/day) to treat acute graft-versus-host disease. CMV infection was more common in those treated with steroids than in those not treated with steroids (70% versus 44%, respectively, P < .05). Overall, 40% of patients had recurrent CMV infection (50% PDN versus 24% no PDN, P < .05). Steroids had no impact on the incidence of CMV infection or its recurrence in HR patients; however, steroids did prolong the need for antiviral treatment. The incidence of CMV infection in IR patients was higher in those receiving PDN (80% PDN versus 41% no PDN, P = .01); recurrence rates were also higher (55% PDN versus 18% no PDN, P = .02). We analyzed CMV-specific immune reconstitution in the first 22 patients of th...Continue Reading
References
Aug 25, 2001·Blood·J W GratamaJ J Cornelissen
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Per LjungmanCarlos Paya
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark R WillsAndrew J Carmichael
Apr 13, 2004·Bone Marrow Transplantation·P LjungmanUNKNOWN European Group for Blood and Marrow Transplantation
Jun 3, 2004·Human Immunology·Paul Moss, Naeen Khan
Jun 19, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Simon F LaceyJohn A Zaia
Aug 29, 2007·Bone Marrow Transplantation·G AvetisyanP Ljungman
Feb 5, 2008·Haematologica·Daniele LilleriGiuseppe Gerna
May 6, 2008·Cytometry. Part B, Clinical Cytometry·Jan W GratamaJan J Cornelissen
Jul 1, 2008·Bone Marrow Transplantation·P LjungmanUNKNOWN European Conference on Infections in Leukemia
Sep 25, 2008·Bone Marrow Transplantation·P Ljungman
Dec 24, 2008·Bone Marrow Transplantation·B PourgheysariP A H Moss
Mar 21, 2009·Blood·Michael Boeckh, Per Ljungman
Apr 17, 2009·Blood·Wendi ZhouDon J Diamond
Jul 21, 2009·Bone Marrow Transplantation·N TormoD Navarro
Sep 12, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A J EidR R Razonable
Sep 15, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marcie TomblynUNKNOWN Centers for Disease Control and Prevention
Sep 15, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Emilia JaskulaAndrzej Lange
May 12, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Domenico PastoreGiorgina Specchia
May 22, 2010·International Journal of Hematology·Martin Schmidt-HieberI W Blau
May 29, 2010·Blood·Jan W GratamaPaula C Southwick
Jun 1, 2010·Journal of Medical Virology·Nuria TormoDavid Navarro
Jan 18, 2011·Hematology/oncology Clinics of North America·Per LjungmanMichael Boeckh
May 23, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Per LjungmanUNKNOWN Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation
Oct 9, 2014·Current Opinion in Hematology·Hermann EinseleGötz Ulrich Grigoleit
Oct 30, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Per LjungmanUNKNOWN Disease Definitions Working Group of the Cytomegalovirus Drug Development Forum