Deleterious epistatic interactions between electron transport system protein-coding loci in the copepod Tigriopus californicus.

Genetics
Christopher S Willett

Abstract

The nature of epistatic interactions between genes encoding interacting proteins in hybrid organisms can have important implications for the evolution of postzygotic reproductive isolation and speciation. At this point very little is known about the fitness differences caused by specific closely interacting but evolutionarily divergent proteins in hybrids between populations or species. The intertidal copepod Tigriopus californicus provides an excellent model in which to study such interactions because the species range includes numerous genetically divergent populations that are still capable of being crossed in the laboratory. Here, the effect on fitness due to the interactions of three complex III proteins of the electron transport system in F2 hybrid copepods resulting from crosses of a pair of divergent populations is examined. Significant deviations from Mendelian inheritance are observed for each of the three genes in F2 hybrid adults but not in nauplii (larvae). The two-way interactions between these genes also have a significant impact upon the viability of these hybrid copepods. Dominance appears to play an important role in mediating the interactions between these loci as deviations are caused by heterozygote/homozyg...Continue Reading

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Citations

Oct 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Christopher K Ellison, Ronald S Burton
Jul 28, 2009·BMC Evolutionary Biology·Benjamin M FitzpatrickS Randal Voss
Sep 14, 2011·Annual Review of Genetics·Shamoni Maheshwari, Daniel A Barbash
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Apr 1, 2008·The American Naturalist·Benjamin M Fitzpatrick
May 21, 2009·Evolution; International Journal of Organic Evolution·Suzanne EdmandsAnnmarie S Hwang
Dec 18, 2007·Evolution; International Journal of Organic Evolution·Christopher K Ellison, Ronald S Burton
Apr 17, 2010·Evolution; International Journal of Organic Evolution·Christopher S Willett
Aug 30, 2014·Zoologica Scripta·Luise KruckenhauserElisabeth Haring
May 14, 2016·G3 : Genes - Genomes - Genetics·Christopher S WillettLydia Hatfield

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