Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration

Nutrients
María G ZubiríaAndrés Giovambattista

Abstract

Modern lifestyle and diets have been associated with metabolic disorders and an imbalance in the normal gut microbiota. Probiotics are widely known for their health beneficial properties targeting the gut microbial ecosystem. The aim of our study was to evaluate the preventive effect ofLactobacillus kefiri(L. kefiri) administration in a fructose-rich diet (FRD) mice model. Mice were provided with tap water or fructose-added (20%w/v) drinking water supplemented or not withL. kefiri. Results showed that probiotic administration prevented weight gain and epidydimal adipose tissue (EAT) expansion, with partial reversion of the adipocyte hypertrophy developed by FRD. Moreover, the probiotic prevented the increase of plasma triglycerides and leptin, together with the liver triglyceride content. Leptin adipocyte secretion was also improved byL. kefiri, being able to respond to an insulin stimulus. Glucose intolerance was partially prevented byL. kefiritreatment (GTT) and local inflammation (TNFα; IL1β; IL6 and INFγ) was completely inhibited in EAT.L. kefirisupplementation generated an impact on gut microbiota composition, changingBacteroidetesandFirmicutesprofiles. Overall, our results indicate that the administration of probiotics pr...Continue Reading

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Citations

Jul 13, 2019·Frontiers in Immunology·Mariano MalamudMaría de Los Ángeles Serradell
May 13, 2018·Annual Review of Nutrition·Ronaldo P FerrarisChirag R Patel
Jun 5, 2019·Nutrients·Conor SlatteryPaul W O'Toole
Jun 5, 2021·BMC Microbiology·Jinhee KimRonaldo P Ferraris

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

GraphPad
Image Pro - Plus
Graph Pad Prism
GraphPad Prism
SPSS
PyElph

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