PMID: 9539759May 16, 1998Paper

Deleterious mutations destabilize ribosomal RNA in endosymbiotic bacteria

Proceedings of the National Academy of Sciences of the United States of America
J D Lambert, N A Moran

Abstract

In populations that are small and asexual, mutations with slight negative effects on fitness will drift to fixation more often than in large or sexual populations in which they will be eliminated by selection. If such mutations occur in substantial numbers, the combined effects of long-term asexuality and small population size may result in substantial accumulation of mildly deleterious substitutions. Prokaryotic endosymbionts of animals that are transmitted maternally for very long periods are effectively asexual and experience smaller effective population size than their free-living relatives. The contrast between such endosymbionts and related free-living bacteria allows us to test whether a population structure imposing frequent bottlenecks and asexuality does lead to an accumulation of slightly deleterious substitutions. Here we show that several independently derived insect endosymbionts, each with a long history of maternal transmission, have accumulated destabilizing base substitutions in the highly conserved 16S rRNA. Stabilities of Domain I of this subunit are 15-25% lower in endosymbionts than in closely related free-living bacteria. By mapping destabilizing substitutions onto a reconstructed phylogeny, we show that ...Continue Reading

References

Oct 1, 1992·Biochemical Genetics·R E OwenD B McCorquodale
Feb 1, 1992·Journal of Molecular Evolution·N Sueoka
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S L O'NeillH M Robertson
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J A JaegerM Zuker
Oct 1, 1993·Medical and Veterinary Entomology·C E TaylorV Petrarca
Jan 1, 1996·Nucleic Acids Research·B L MaidakC R Woese
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·N A Moran
Sep 1, 1997·Molecular Biology and Evolution·M Lynch
May 1, 1964·Mutation Research·H J MULLER
Jan 1, 1997·Annual Review of Entomology·J H Werren

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Citations

Dec 16, 2004·Journal of Molecular Evolution·Jennifer J Wernegreen, Daniel J Funk
Oct 6, 2004·Journal of Molecular Evolution·Lauren Ancel MeyersAndrew D Ellington
Jul 8, 2000·Trends in Ecology & Evolution·N A Moran, J J Wernegreen
Oct 19, 2000·Research in Microbiology·C Boursaux-Eude, R Gross
Dec 23, 1999·Current Opinion in Genetics & Development·J O Andersson, S G Andersson
Jun 14, 2000·Current Opinion in Microbiology·N A Moran, P Baumann
Sep 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ivica TamasSiv G E Andersson
Nov 26, 2011·Genome Biology and Evolution·Yogeshwar D Kelkar, Howard Ochman
Sep 25, 2008·Molecular Biology and Evolution·Steven E Massey
Nov 6, 2008·Molecular Biology and Evolution·Kevin J BalbiEdward J Feil
Jan 8, 2009·Molecular Biology and Evolution·Christina Toft, Mario A Fares
Nov 20, 2009·Molecular Biology and Evolution·Dean M Castillo, Teresa E Pawlowska
Nov 7, 2003·Nucleic Acids Research·Danny Barash
Jun 13, 2012·Nucleic Acids Research·Allison K Hansen, Nancy A Moran
Feb 22, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Angela E Douglas, John A Raven
Apr 21, 2009·Journal of Bacteriology·Rahul RaghavanMichael F Minnick
Jul 9, 2008·Journal of Bacteriology·Rahul RaghavanMichael F Minnick
Dec 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·C G Kurland, S G Andersson
Dec 14, 2004·Microbiology and Molecular Biology Reviews : MMBR·Evelyn ZientzRoy Gross
Sep 13, 2005·Annual Review of Microbiology·Paul Baumann
Jul 11, 2006·Annual Review of Microbiology·Michael Lynch
Feb 8, 2005·Genome Biology·Alexis DufresneFrédéric Partensky
Mar 17, 2004·PLoS Biology·Jennifer J Wernegreen
May 14, 2010·PLoS Computational Biology·Raul MendezUgo Bastolla
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Takeshi ItohMasatoshi Nei
Jul 12, 2014·The ISME Journal·Allison K Hansen, Patrick H Degnan
Aug 19, 2008·The American Naturalist·Nancy A Moran
Feb 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Gordon M Bennett, Nancy A Moran
Nov 9, 2007·Research in Microbiology·Kevin J Balbi, Edward J Feil
Apr 14, 2015·Annals of the New York Academy of Sciences·Jennifer J Wernegreen
Apr 22, 2005·Journal of Evolutionary Biology·M A FaresE Barrio
Dec 12, 2007·Evolution; International Journal of Organic Evolution·Brendan O'Fallon
Jan 8, 2013·Evolution; International Journal of Organic Evolution·Nicholas W VankurenTeresa E Pawlowska
Jul 28, 2012·Evolution; International Journal of Organic Evolution·Stephen J MondoTeresa E Pawlowska
Oct 20, 2004·Journal of Molecular Biology·Ugo BastollaRoeland C H J van Ham
Jun 12, 2001·Molecular Phylogenetics and Evolution·J J WernegreenN A Moran

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