Deleterious mutations, variable epistatic interactions, and the evolution of recombination

Theoretical Population Biology
S P Otto, M W Feldman

Abstract

In this paper, we examine the conditions that allow increased recombination to evolve in the presence of recurrent deleterious mutation. We focus on a three-locus model first studied by Feldman et al. (1980), which follows the dynamics of a modifier locus that alters the recombination rate between two loci subject to deleterious mutation. Although Feldman et al. (1980) indicated that increased recombination might be favored if there is diminishing-returns epistasis, we show that alleles that increase the recombination rate can only invade if there is synergistic epistasis between the loci under selection. Even with synergistic epistasis, evolution at the modifier locus will lead to decreased recombination if the modifier locus is loosely linked and epistasis is strong. Using the multi-locus analysis of Barton (1995), we show that variability among loci in the sign and strength of epistasis further decreases the parameter space over which increased recombination may evolve. We conclude that, even with negative epistasis, increased recombination may only be favored when linkage is tight, especially if, as seems likely, epistatic interactions are highly variable among loci.

References

Jun 1, 1972·Theoretical Population Biology·S Karlin, J McGregor
Sep 1, 1972·Theoretical Population Biology·M W Feldman
May 1, 1970·Theoretical Population Biology·I Eshel, M W Feldman
Apr 1, 1995·Genetical Research·N H Barton
Jun 1, 1995·Theoretical Population Biology·M NordborgM W Feldman
Jan 1, 1993·Human Mutation·A S Kondrashov, J F Crow
Sep 1, 1993·The Journal of Heredity·B Charlesworth
Sep 1, 1993·The Journal of Heredity·A S Kondrashov
Feb 1, 1996·Genetical Research·B Charlesworth, N H Barton
Jan 1, 1996·Annual Review of Genetics·M W FeldmanF B Christiansen
May 1, 1964·Mutation Research·H J MULLER
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M W FeldmanL D Brooks
Dec 1, 1966·Genetics·M Kimura, T Maruyama

❮ Previous
Next ❯

Citations

Oct 30, 2009·Proceedings of the National Academy of Sciences of the United States of America·Benjamin CallahanBoris I Shraiman
Mar 3, 2010·The Journal of Heredity·David W HallSara C Pope
May 7, 2010·The Journal of Heredity·Rolf LohausRicardo B R Azevedo
Mar 5, 2010·The Journal of Heredity·Dusan MisevicRichard E Lenski
Sep 4, 2009·Molecular Biology and Evolution·Darin R Rokyta, Holly A Wichman
Feb 12, 2005·Proceedings. Biological Sciences·Tim F CooperSantiago F Elena
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·N H Barton
Dec 7, 2000·Evolution; International Journal of Organic Evolution·M C Whitlock, D Bourguet
Apr 17, 2007·BMC Evolutionary Biology·Niko BeerenwinkelRichard E Lenski
Jul 2, 2008·BMC Evolutionary Biology·Lena Wilfert, Paul Schmid-Hempel
Sep 19, 2009·PLoS Computational Biology·Dusan MisevicSebastian Bonhoeffer
Sep 15, 2010·PLoS Genetics·C Scott WylieHerbert Levine
Feb 3, 2005·Genetics·N H Barton, Sarah P Otto
Mar 23, 2005·Genetics·Denis Roze, Thomas Lenormand
Jun 10, 2005·Genetics·John K Kelly
Mar 21, 2006·Genetics·Roger D KouyosSebastian Bonhoeffer
May 17, 2006·Genetics·Denis Roze, Nick H Barton
Aug 5, 2009·Genetics·Olivier C Martin, Andreas Wagner
Jan 20, 2010·Genetics·Denis Roze, Richard E Michod
Dec 23, 2009·Genetics·Hong GaoMarcus W Feldman
Jul 2, 2010·Chaos·Santiago F ElenaJosep Sardanyés
Sep 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Rafael Sanjuán, Santiago F Elena
Jul 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Thomas MacCarthy, Aviv Bergman
Dec 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Uri Liberman, Marcus W Feldman
Oct 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rafael SanjuánSantiago F Elena
Jan 9, 2014·Heredity·H G Spencer, A G Clark
Jan 11, 2007·The American Naturalist·Andy GardnerNicholas H Barton
Nov 28, 2014·Proceedings of the National Academy of Sciences of the United States of America·Oana CarjaMarcus W Feldman
Dec 15, 2015·Genome Biology and Evolution·Alexander E LobkovskyEugene V Koonin
Aug 24, 2010·Journal of Theoretical Biology·Dorota MackiewiczStanisław Cebrat
Apr 30, 2008·Theoretical Population Biology·Denis Roze, François Rousset
Feb 26, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Richard E MichodAurora M Nedelcu
Mar 6, 2007·Trends in Ecology & Evolution·Roger D KouyosSebastian Bonhoeffer
Jul 22, 2005·Journal of Evolutionary Biology·J M RosaA García-Dorado
Nov 25, 2003·Evolution; International Journal of Organic Evolution·Susanne Paland, Bernhard Schmid

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.