Deleterious tissue reaction to an alkylene bis(dilactoyl)-methacrylate bone adhesive in long-term follow up after screw augmentation in an ovine model

Biomaterials
Lars GrossterlindenWolfgang Linhart

Abstract

Biomaterials are designed to support orthopedic surgeons and once implanted they will help the body to heal itself. In this way one of the most attractive substances are biomaterials that allow gluing of bone fragments and implant fixation. Although no bone adhesive is established for practical use in clinical practice yet, there is evidence in vitro and in vivo that a new class of bone adhesives based on alkylene bis(dilactoyl)-methacrylates may meet the requirements to bridge the gap between bench and bedside. The purpose of this experimental study was to investigate the long-term biocompatibility as well as the integration in the remodeling process of a new polymer of this group of substances that was used for both fragment adaptation and implant fixation in a large-scale animal model. In 24 sheep the lateral tibial condyle was osteotomized and refixed by three cortical screws. In 12 of them overdrilling the bone thread of one screw was performed to simulate the poor mechanical properties of osteoporotic bone and the polymer was used in this setting for screw augmentation, furthermore the osteotomy surface was covered with polymer before osteosynthesis to analyze the influence of the material on bone healing. In the other 12...Continue Reading

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Citations

Jun 11, 2010·Journal of Biomaterials Science. Polymer Edition·Christian HeissReinhard Schnettler
May 21, 2008·Biomedical Engineering Online·Kira EndresRalf Smeets
Sep 9, 2010·Expert Review of Medical Devices·Henry T Peng, Pang N Shek
Nov 5, 2013·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Vedat UrucFatih Küçükdurmaz
Apr 29, 2008·Biomaterials·David F Williams
Nov 6, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·C HeissR Schnettler
Jan 3, 2013·Journal of Biomedical Materials Research. Part a·Ralf SmeetsAndreas Kolk
Oct 6, 2011·Acta Biomaterialia·Ziyang ZhangArndt F Schilling
Mar 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoyi ChenZhongru Gou
Apr 2, 2010·ACS Applied Materials & Interfaces·Axel NordbergMichael Malkoch
Apr 20, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Machteld Van ErkHarry Van Goor

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