PMID: 6408473Jun 1, 1983Paper

Deletion induction in bacteria. I. The role of mutagens and cellular error-prone repair

Mutation Research
E BalbinderC I Reich

Abstract

The amber mutation trpD28 of Salmonella typhimurium shows a complex reversion pattern on anthranilate (AA)-supplemented minimal medium. Under such conditions it is possible to recover revertants of two phenotypes, prototrophs (MM+) and anthranilate utilizers (AA+), each phenotype brought about by several mutational events. Since one class of AA+ revertants is caused by deletion of the trpD28 mutation, this constitutes a useful system for quantitative studies of the effects of mutagenic agents and cellular factors on the production of deletions. In the present study we have tried to assess the relative contribution of chemical mutagens vs. cellular mutator factors in causing this class of mutations. Strains of S. typhimurium in which the spontaneous reversion rate of trpD28 was modified by pKM101, (strain SO1007), mutL (strain SO1018) and both (strain SO1008), as well as the wild type (strain SO939) were treated with nitrous acid (HNO2) and mitomycin C (MC), mutagens reported to induce deletions in bacteria. The results showed that while the absolute frequency of deletions increased exponentially with dose of mutagen in parallel with the total reversion frequency, the relative frequency (percent) of these mutations was character...Continue Reading

References

Jan 1, 1977·Mutation Research·F Zimmermann
Jun 8, 1977·Molecular & General Genetics : MGG·S Tanemura, R Bauerle
Jan 1, 1977·Annual Review of Genetics·R A Weisberg, S Adhya
Jan 2, 1979·Molecular & General Genetics : MGG·K E Mortelmans, B A Stocker
Jul 1, 1979·Mutation Research·A Goze, R Devoret
May 1, 1979·Genetics·I HoppeJ R Roth
Dec 1, 1979·Journal of Bacteriology·R G FowlerK E Mortelmans
Feb 9, 1979·Science·F J de Serres, M D Shelby
Jan 1, 1976·Annual Review of Biochemistry·J W Drake, R H Baltz
Dec 1, 1976·Bacteriological Reviews·E M Witkin
Jan 1, 1976·Annual Review of Genetics·E C Cox
Jan 1, 1972·Molecular & General Genetics : MGG·H Schmieger
Jun 1, 1968·Journal of Bacteriology·E BalbinderH Tamaki
Feb 1, 1969·Genetics·D O Schwartz, J R Beckwith
Nov 1, 1966·Journal of Bacteriology·C E Kirchner, M J Rudden
Jan 1, 1981·Annual Review of Biochemistry·M J Waring
Jan 29, 1981·Nature·J Cairns
Apr 1, 1981·Journal of Bacteriology·K M Overbye, P Margolin
May 1, 1982·Cell·J W Little, D W Mount
Oct 1, 1962·Journal of Molecular Biology·I TESSMAN
Jan 1, 1960·Genetics·T Miyake

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.