Deletion mapping of chromosome region 12q13-24 in colorectal cancer

Cancer Genetics and Cytogenetics
Turkan AytekinBeyhan Cengiz

Abstract

Colorectal cancer is one of the most common cancers in the world. Colorectal cancer develops after a long and multistep process of carcinogenesis. Inactivation of tumor suppressor genes is among the most important steps in development of colorectal cancer. Analysis of loss of heterozygosity (LOH) is an effective method to determine the localization of tumor suppressor genes. In this study, we used five microsatellite markers to analyze the region 12q13-24 among 47 patients with colorectal cancer. The frequency of LOH and the clinicopathological data were compared using logistic regression and a chi-square test. In 34 of 47 tumor tissues (72%), LOH was detected at least in one marker. The highest LOH frequency was 34%, on the D12S129 locus; the lowest frequency was 23%, on the D12S78 locus. Loss of heterozygosity was detected as 32% on D12S83, 30% on D12S346, and 26% on D12S1660. No statistically significant correlation was found between the frequency of LOH and clinicopathological features (P > 0.05). Chromosome region 12q13-24 contains several known genes that may be candidate tumor suppressor genes, including RASAL1, ITGA7, STAB2, GLIPR1, and SLC5A8. Although the exact roles of these genes in colorectal cancer formation remai...Continue Reading

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Citations

Jul 9, 2013·The American Journal of Pathology·Lang-Zhu TanJian-Hua Luo
Jul 4, 2018·Disease Models & Mechanisms·Andromeda Van RotenKaren Smeets
Sep 26, 2014·World Journal of Gastroenterology : WJG·Branislav RovcaninPetar Ivanovski
Jul 1, 2016·Porto Biomedical Journal·Pedro Gonçalves, Fátima Martel
Mar 21, 2021·Cancer Gene Therapy·Junjie WangXiumei Sheng

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