Deletion of 1p36 in childhood endodermal sinus tumors by two-color fluorescence in situ hybridization: a pediatric oncology group study

Genes, Chromosomes & Cancer
E J PerlmanA T Look

Abstract

Childhood endodermal sinus tumors (CESTs) are a unique category of germ cell tumors involving the testis and extragonadal region in children less than 4 years of age. Recent studies of CEST have shown recurrent cytogenetic abnormalities involving the short arm of chromosome 1, most commonly, a deletion of distal 1p. Experience with neuroblastomas has shown that cytogenetic analyses may underestimate the frequency of 1p deletion. To determine the frequency of deletion of Ip in CEST and to verify that 1p is, in fact, deleted and not translocated, we analyzed ten tumors by two-color fluorescence in situ hybridization on single-cell suspensions of interphase nuclei by using a cosmid probe from the PITSLRE kinase (p58) locus (previously mapped to 1p36) cohybridized with plasmid probe pUC1.77 (which recognizes the 1q heterochromatic region) to determine the copy number of chromosome 1. Eight of the ten tumors examined showed evidence of deletion of 1p36. Five of the eight tumors exhibited multiple subdones, and all subdones showed deletion of at least one copy of 1p36, indicating that the deletion probably occurred before the development of chromosome 1 aneusomy. We conclude that deletions of the short arm of chromosome 1, specifical...Continue Reading

References

Jun 1, 1992·The American Journal of Surgical Pathology·A K el-NaggarJ G Batsakis
May 1, 1992·The American Journal of Pediatric Hematology/oncology·G M Brodeur, A Nakagawara
Mar 1, 1992·Cancer Genetics and Cytogenetics·N B Atkin, M C Baker
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B A BunnellV J Kidd
Nov 1, 1990·Cancer Genetics and Cytogenetics·V V MurtyR S Chaganti
Nov 1, 1989·Genes, Chromosomes & Cancer·A WeithM Schwab
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C T FongG M Brodeur
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·N C DracopoliR F Kefford
Oct 15, 1989·Cancer Genetics and Cytogenetics·P Dal CinH Van den Berghe
Nov 1, 1988·Cancer Genetics and Cytogenetics·J W OosterhuisJ B Leeuw
Jan 15, 1986·Cancer Genetics and Cytogenetics·Z GibasA A Sandberg
Jun 1, 1987·Cancer Genetics and Cytogenetics·N B Atkin, M C Baker
Aug 1, 1994·Genes, Chromosomes & Cancer·G SchleiermacherO Delattre
Jan 1, 1995·Molecular and Cellular Biology·J M LahtiV J Kidd
Mar 1, 1994·Cancer Genetics and Cytogenetics·F H ThompsonR Makar
May 1, 1994·Cancer Genetics and Cytogenetics·L HoffnerU Surti

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Citations

Jul 24, 2003·The American Journal of Pathology·Noriko KatoTeiichi Motoyama
Jun 20, 2002·Cancer Genetics and Cytogenetics·Jannie van EchtenBauke de Jong
Feb 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M E BlohmU Göbel
May 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C R Pinkerton
May 20, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Imke M VeltmanAd Geurts van Kessel
Jan 4, 1998·Journal of Pediatric Hematology/oncology·J A Biegel
Apr 25, 2000·Journal of Pediatric Hematology/oncology·E J PerlmanR P Castleberry
Aug 19, 2007·Molecular and Cellular Biology·Hongliang ZongJianxin Gu
Sep 28, 2002·International Journal of Cancer. Journal International Du Cancer·Beatriz Martinez-DelgadoJavier Benítez
Mar 29, 2002·Genes, Chromosomes & Cancer·Dominik T SchneiderElizabeth J Perlman
Aug 28, 2007·Surgical Oncology·Zachary HortonSarah Schultz
Jul 28, 2011·Pediatric Blood & Cancer·William E HaskinsElizabeth J Perlman
Jan 5, 2005·Biochemical and Biophysical Research Communications·Zejuan LiJianxin Gu
Mar 29, 2007·Carcinogenesis·Anupama ChandramouliMark A Nelson
Nov 12, 2002·Medical and Pediatric Oncology·Martin BeneschChristian Urban
Jul 25, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·M MostertL Looijenga
Oct 30, 2019·International Journal of Molecular Sciences·Leendert H J LooijengaMuhammad T Idrees
Jun 24, 2020·Translational Psychiatry·Bochao Danae LinJacob Vorstman
Dec 30, 1999·Current Problems in Cancer·F J Rescorla, P P Breitfeld

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