PMID: 7519870May 1, 1994Paper

Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia

Genes, Chromosomes & Cancer
L P MenasceC J Harrison

Abstract

We have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphoblastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing terminal deletions of 6q. We demonstrated by FISH that in all cases the deletions were interstitial. D6S246 (6q16.3) was the only marker which was missing in all six cases, indicating a common region of deletion between the markers M6P1 at 6q14-15 and FYN at 6q21. Our results suggest the presence of a tumour suppressor gene within this interval.

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Citations

Feb 18, 1998·International Journal of Cancer. Journal International Du Cancer·M KondoT Takahashi
Apr 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·V OrphanosJ M Boyle
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A. KoulÅ. Borg Å
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Aug 28, 2002·Reviews in Clinical and Experimental Hematology·Christine J Harrison, Letizia Foroni
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