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Deletion of a non-canonical promoter regulatory element causes loss of Scn1a expression and epileptic phenotypes in mice

bioRxiv

Sep 12, 2019

Jessica L HaighAlex S Nord

Abstract

Genes with multiple co-active promoters appear common in brain, yet little is known about functional requirements for these potentially redundant genomic regulatory elements. SCN1A, which encodes the NaV1.1 sodium channel alpha subunit, is one such gene with two co-active promoters. Mut...read more

Mentioned in this Paper

Genes
Infantile Severe Myoclonic Epilepsy
Epilepsy
NAV1.1 Voltage-Gated Sodium Channel
Transcription, Genetic
Brain
Genomic Stability
Gene Deletion
Promoter
SCN1A gene
10
3
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Deletion of a non-canonical promoter regulatory element causes loss of Scn1a expression and epileptic phenotypes in mice

bioRxiv

Sep 12, 2019

Jessica L HaighAlex S Nord

DOI: 10.1101/766634

Abstract

Genes with multiple co-active promoters appear common in brain, yet little is known about functional requirements for these potentially redundant genomic regulatory elements. SCN1A, which encodes the NaV1.1 sodium channel alpha subunit, is one such gene with two co-active promoters. Mut...read more

Mentioned in this Paper

Genes
Infantile Severe Myoclonic Epilepsy
Epilepsy
NAV1.1 Voltage-Gated Sodium Channel
Transcription, Genetic
Brain
Genomic Stability
Gene Deletion
Promoter
SCN1A gene
10
3

Similar Papers Found In These Feeds

Paper Details
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