Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice.

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Masanobu TsudaM Eric Gershwin

Abstract

Mice with a dominant-negative transforming growth factor β receptor restricted to T cells (dnTGFβRII mice) develop an inflammatory biliary ductular disease that strongly resembles human primary biliary cirrhosis (PBC). Furthermore, deletion of the gene encoding interleukin (IL)-12p40 resulted in a strain (IL-12p40(-/-) dnTGFβRII) with dramatically reduced autoimmune cholangitis. To further investigate the role of the IL-12 cytokine family in dnTGFβRII autoimmune biliary disease, we deleted the gene encoding the IL-12p35 subunit from dnTGFβRII mice, resulting in an IL-12p35(-/-) dnTGFβRII strain which is deficient in two members of the IL-12 family, IL-12 and IL-35. In contrast to IL-12p40(-/-) mice, the IL-12p35(-/-) mice developed liver inflammation and bile duct damage with similar severity but delayed onset as the parental dnTGFβRII mice. The p35(-/-) mice also demonstrated a distinct cytokine profile characterized by a shift from a T-helper 1 (Th1) to a Th17 response. Strikingly, liver fibrosis was frequently observed in IL-12p35(-/-) mice. In conclusion, IL-12p35(-/-) dnTGFβRII mice, histologically and immunologically, reflect key features of PBC, providing a useful generic model to understand the immunopathology of human ...Continue Reading

References

Nov 1, 1995·The Journal of Experimental Medicine·M F NeurathW Strober
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O M MartinezS M Krams
Jul 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MotekiM E Gershwin
Apr 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K HaradaM E Gershwin
Jan 14, 2000·Journal of Clinical Immunology·T NaganoT Tsuji
Aug 2, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H MiyakawaM E Gershwin
Feb 4, 2003·Nature Reviews. Immunology·Giorgio Trinchieri
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhe-Xiong LianM Eric Gershwin
Nov 24, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tin K MaoM Eric Gershwin
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
May 4, 2006·The Journal of Clinical Investigation·David YenDonna Rennick
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sabine OerteltM Eric Gershwin
Jan 5, 2007·Annual Review of Immunology·Casey T WeaverLaurie E Harrington
Nov 23, 2007·Nature·Lauren W CollisonDario A A Vignali
Dec 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ya-Hui ChuangM Eric Gershwin
Dec 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Eric Gershwin, Ian R Mackay
Jan 22, 2008·Journal of Tropical Pediatrics·Anoop S PulickalAndrew J Pollard
May 3, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guo-Xiang YangM Eric Gershwin
Nov 4, 2008·Annual Review of Medicine·Clara Abraham, Judy H Cho
Dec 23, 2008·Journal of Autoimmunity·Ruth Y Z LanM Eric Gershwin
Jan 24, 2009·Immunological Reviews·Lauren W Collison, Dario A A Vignali
Jan 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Arnaud LemmersJacques Devière
May 22, 2009·The New England Journal of Medicine·Gideon M HirschfieldKatherine A Siminovitch
Aug 14, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Katsunori YoshidaM Eric Gershwin
Mar 23, 2010·Cellular & Molecular Immunology·Fouad LafdilBin Gao
Jun 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Weici ZhangM Eric Gershwin
Sep 22, 2010·The Journal of Experimental Medicine·Philip L SimonianAndrew P Fontenot
Nov 16, 2010·Journal of Autoimmunity·Cynthia L Hickman-BrecksPaul M Allen
Jan 13, 2011·International Journal of Molecular Medicine·Liyun WangKeshu Xu
Sep 9, 2011·Current Opinion in Immunology·Anneli PetersVijay K Kuchroo

❮ Previous
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Citations

Mar 12, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sunyi YeShusen Zheng
Jan 1, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chen-Yen YangM Eric Gershwin
Sep 9, 2015·Journal of Autoimmunity·G J Webb, G M Hirschfield
Feb 1, 2014·European Journal of Immunology·Marco CarbonePietro Invernizzi
Aug 8, 2015·Journal of Autoimmunity·G J WebbG M Hirschfield
Apr 16, 2014·The American Journal of Pathology·Yan WangBin Gao
Jul 21, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yury Popov
Mar 28, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kazuhito KawataM Eric Gershwin
Dec 6, 2014·Journal of Digestive Diseases·Xiao Gang Xiang, Qing Xie
Jan 8, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Pietro Invernizzi, M Eric Gershwin
Aug 29, 2013·Clinical and Experimental Immunology·H TanakaM E Gershwin
Oct 4, 2014·Clinical Reviews in Allergy & Immunology·Shang-An ShuPatrick S C Leung
Jan 13, 2015·Clinical and Experimental Immunology·H TanakaM E Gershwin
Jan 27, 2015·Clinical Reviews in Allergy & Immunology·Jinjung ChoiM Eric Gershwin
Mar 11, 2015·Journal of Applied Toxicology : JAT·Xinzhi WangZhenzhou Jiang
Aug 13, 2015·Clinical Reviews in Allergy & Immunology·Yu-Qing XieZhe-Xiong Lian
Jan 16, 2014·Autoimmunity Reviews·Christopher L Bowlus, M Eric Gershwin
Aug 31, 2014·Clinical Reviews in Allergy & Immunology·Marion J Pollheimer, Peter Fickert
Sep 11, 2014·Clinical Reviews in Allergy & Immunology·Annarosa FloreaniAlbert Pares
Mar 17, 2015·Clinical Reviews in Allergy & Immunology·Tomohiro KatsumiYoshiyuki Ueno
Sep 23, 2014·Clinical Reviews in Allergy & Immunology·Ying SunM Eric Gershwin
May 9, 2014·Clinical Reviews in Allergy & Immunology·Annarosa FloreaniM Eric Gershwin
Apr 16, 2013·Gastroenterology·Gideon M HirschfieldAndrew L Mason
Oct 16, 2014·Autoimmunity Reviews·Naseeha IslamM Eric Gershwin
Dec 29, 2018·Expert Review of Clinical Immunology·Man LuoYong Zhou
Jul 2, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Kexin ShenHaishan Zhang
Oct 22, 2019·Journal of Cellular Biochemistry·Zahra YazdaniSasan Ghaffari
Jun 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lindsey KennedyGianfranco Alpini
Jun 26, 2015·World Journal of Gastroenterology : WJG·Zhi-Zhi XingJi-Dong Jia
Aug 9, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaogang PengJie Du
Oct 20, 2015·World Journal of Gastroenterology : WJG·Li-Sha ChengWei Jiang
May 22, 2019·Journal of Digestive Diseases·Vincenzo RoncaPietro Invernizzi
Dec 28, 2018·Scandinavian Journal of Immunology·Jie GuoAmmei Deng
Feb 23, 2020·Clinical Reviews in Allergy & Immunology·Shou-Pei LiuZhe-Xiong Lian
Oct 24, 2017·Hepatology Communications·Atsushi TanakaaM Eric Gershwin

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