Deletion of Maged1 in mice abolishes locomotor and reinforcing effects of cocaine

EMBO Reports
Jean-François De BackerAlban de Kerchove d'Exaerde

Abstract

Melanoma antigen genes (Mage) were first described as tumour markers. However, some of Mage are also expressed in healthy cells where their functions remain poorly understood. Here, we describe an unexpected role for one of these genes, Maged1, in the control of behaviours related to drug addiction. Mice lacking Maged1 are insensitive to the behavioural effects of cocaine as assessed by locomotor sensitization, conditioned place preference (CPP) and drug self-administration. Electrophysiological experiments in brain slices and conditional knockout mice demonstrate that Maged1 is critical for cortico-accumbal neurotransmission. Further, expression of Maged1 in the prefrontal cortex (PFC) and the amygdala, but not in dopaminergic or striatal and other GABAergic neurons, is necessary for cocaine-mediated behavioural sensitization, and its expression in the PFC is also required for cocaine-induced extracellular dopamine (DA) release in the nucleus accumbens (NAc). This work identifies Maged1 as a critical molecule involved in cellular processes and behaviours related to addiction.

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Citations

Aug 8, 2018·EMBO Reports·Michael Loureiro, Christian Lüscher
Sep 12, 2019·Physiological Reviews·Nora D VolkowRuben Baler
Mar 3, 2020·Neuropharmacology·Matteo Di SegniRossella Ventura
Aug 14, 2021·Translational Psychiatry·Julian Cheron, Alban de Kerchove d'Exaerde

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