Deletion of receptor for advanced glycation end products exacerbates lymphoproliferative syndrome and lupus nephritis in B6-MRL Fas lpr/j mice

The Journal of Immunology : Official Journal of the American Association of Immunologists
Antoine GouryFatouma Touré

Abstract

The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor that interacts with advanced glycation end products, but also with C3a, CpG DNA oligonucleotides, and alarmin molecules such as HMGB1 to initiate a proinflammatory reaction. Systemic lupus erythematosus is an autoimmune disorder associated with the accumulation of RAGE ligands. We generated mice invalidated for RAGE in the lupus-prone B6-MRL Fas lpr/j background to determine the role of RAGE in the pathogenesis of systemic lupus erythematosus. We compared the phenotype of these mice with that of their wild-type and B6-MRL Fas lpr/j littermates. Lymphoproliferative syndrome, production of anti-dsDNA Abs, lupus nephritis, and accumulation of CD3(+)B220(+)CD4(-)CD8(-) autoreactive T cells (in the peripheral blood and the spleen) were significantly increased in B6-MRL Fas lpr/j RAGE(-/-) mice compared with B6-MRL Fas lpr/j mice (respectively p < 0.005, p < 0.05, p < 0.001, and p < 0.001). A large proportion of autoreactive T cells from B6-MRL Fas lpr/j mice expressed RAGE at their surface. Time course studies of annexin V expression revealed that autoreactive T cells in the spleen of B6-MRL Fas lpr/j-RAGE(-/-) mice exhibited a delay in apoptos...Continue Reading

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Citations

Jun 13, 2015·International Journal of Molecular Sciences·Kongyang MaLiwei Lu
Mar 19, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Karim BelmokhtarFatouma Touré
Oct 6, 2018·European Journal of Immunology·Juan Carlos Rodríguez-AlbaLeopoldo Santos-Argumedo
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Nov 13, 2015·Expert Opinion on Therapeutic Targets·Ravichandran RamasamyAnn Marie Schmidt
Apr 4, 2021·Cells·Haruki Watanabe, Myoungsun Son
May 1, 2021·International Journal of Molecular Sciences·Kyoko KawaharaYoshitaka Morita

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