Deletion of the citron kinase gene selectively affects the number and distribution of interneurons in barrelfield cortex

The Journal of Comparative Neurology
Patrizia MuzziAlessandro Vercelli

Abstract

Citron kinase (CIT-K), a ser/thr kinase, is required during neurogenesis for cytokinesis of neuronal precursors. Deletion of the cit-k gene in mice (cit-k(-/-) mice) leads to a severe malformative central nervous system syndrome characterized by microencephaly, ataxia, and epileptic seizures; affected mice die by the third week of postnatal life. We have used NADPH-diaphorase histochemistry, immunostaining for calbindin, calretinin, parvalbumin, and glutamic acid decarboxylase 67 (GAD67), and histological staining to undertake qualitative and quantitative analyses of the morphology and distribution of interneurons in the barrelfield cortex of cit-k(-/-) mice. By postnatal day 13, lack of CIT-K results in profoundly altered cortical cell morphology: the infragranular layers are populated by large, binucleate interneurons bearing many more dendrites than in control mice, an anatomical profile that has also been reported for the cortex of humans with cortical dysplasias and epilepsy. Tessellation analyses reveal that a clustered distribution of interneurons is maintained in cit-k(-/-) mice, but that their nearest neighbor distance is significantly increased, and thus their density is reduced; the overall number of interneurons is ...Continue Reading

References

Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
May 22, 1991·The Journal of Comparative Neurology·A E HendricksonM R Celio
Sep 1, 1990·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·J R Glaser, E M Glaser
Jan 1, 1989·Trends in Neurosciences·J R Naegele, C J Barnstable
Dec 1, 1987·Journal of Neurocytology·A CobasH Van der Loos
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S H HendryP C Emson
Jan 1, 1994·Journal of Neuroscience Methods·C DuyckaertsJ J Hauw
Sep 1, 1993·Journal of Neurocytology·M E Dennison-CavanaghJ G Parnavelas
May 1, 1996·Trends in Neurosciences·J G JefferysM A Whittington
Jun 1, 1997·Cerebral Cortex·Y Gonchar, A Burkhalter
Sep 22, 2000·Epilepsia·R SpreaficoC Munari
Nov 22, 2000·Brain Research. Brain Research Reviews·F CicchettiA Parent
Mar 20, 2001·Nature Reviews. Neuroscience·C J McBain, A Fisahn
May 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F M Benes, S Berretta
Jul 19, 2001·Cerebral Cortex·M R SarkisianJ J LoTurco
Jun 4, 2002·Nature Reviews. Neuroscience·Bagirathy Nadarajah, John G Parnavelas
Jun 7, 2002·Nature·Kresimir LetinicPasko Rakic
Jul 24, 2002·Brain : a Journal of Neurology·L TassiR Spreafico
Nov 19, 2002·Neuroscience·B CipellettiC Frassoni
May 24, 2003·Brain Research. Developmental Brain Research·Neal R Melvin, Richard H Dyck
May 24, 2003·Cerebral Cortex·Qing XuStewart A Anderson
Jun 5, 2003·Brain Research Bulletin·Ferdinando Di CuntoLorenzo Silengo
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qing XuStewart A Anderson
Apr 30, 2004·Cerebral Cortex·Guillermina López-BenditoOle Paulsen

❮ Previous
Next ❯

Citations

Mar 4, 2009·Journal of Environmental Management·Andrea SchievanoFabrizio Adani
Oct 18, 2014·Frontiers in Neuroanatomy·Kinga Tóth, Zsófia Maglóczky
Aug 16, 2016·Human Genetics·Sulman BasitMohammed I Samman
Apr 30, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Richard NicholasRichard Reynolds
Feb 16, 2017·Cell Reports·Federico Tommaso BianchiFerdinando Di Cunto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.