PMID: 3768957Nov 7, 1986Paper

Deletion of the cytoplasmic domain of the polymeric immunoglobulin receptor prevents basolateral localization and endocytosis

Cell
K E MostovD L Deitcher

Abstract

We deleted the cytoplasmic domain of the polymeric immunoglobulin receptor. When expressed in fibroblasts, the truncated receptor, like the wild-type, reaches the cell surface, can bind ligand, and is cleaved to secretory component. Unlike the wild-type, it is not endocytosed. When expressed in polarized Madin-Darby canine kidney cells, the mutant receptor is transported from the Golgi apparatus directly to the apical surface and cleaved to secretory component. In contrast, the wild-type receptor travels from the Golgi to the basolateral surface and is then endocytosed and sent to the apical surface. These results suggest that the cytoplasmic domain of the receptor is necessary for both basolateral localization and endocytosis.

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Citations

Feb 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K E Mostov, M H Cardone
Jul 1, 1990·The Journal of Membrane Biology·M P LisantiA R Saltiel
Aug 1, 1991·The Journal of Membrane Biology·E SchaererJ P Kraehenbuhl
Aug 1, 1992·Current Opinion in Cell Biology·K S Matlin
Jun 30, 2000·Current Opinion in Cell Biology·K E MostovY Altschuler
Nov 24, 2001·Trends in Cell Biology·W J Nelson, C Yeaman
Mar 2, 2005·Nature Reviews. Molecular Cell Biology·Enrique Rodriguez-BoulanAnne Müsch
Oct 24, 2008·Nature Reviews. Molecular Cell Biology·Ira Mellman, W James Nelson
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S HirschS Gluck
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S KoikeA Nomoto
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·I GeffenM Spiess
May 1, 1990·The Journal of Cell Biology·P LemanskyA M Tartakoff
Oct 1, 1990·The Journal of Cell Biology·A Le BivicE Rodriguez-Boulan
Feb 1, 1992·The Journal of Cell Biology·K MostovC Okamoto
Jul 1, 1991·DNA and Cell Biology·V I Brown, M I Greene
Mar 11, 2000·Molecular Biology of the Cell·Y AltschulerR P Hughey
Dec 18, 1991·European Journal of Biochemistry·E Smythe, G Warren
Jan 1, 1992·Annals of the New York Academy of Sciences·J E Casanova
Aug 1, 1988·Gut·P BrandtzaegT O Rognum

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