Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Joan ClimentAllan Balmain

Abstract

To investigate the role of the PER3 circadian rhythm gene, located within the commonly deleted region of chromosome 1p36, in human breast cancer development. The frequency of genetic alterations at 1p36 and PER3 gene copy number status were analyzed in 180 lymph node-negative breast cancers from patients who had received treatment with chemotherapy and/or tamoxifen. The expression levels of PER3 were also analyzed using published microarray profiles from > 400 breast cancer samples. Finally, the effect of loss of Per3 on tumor susceptibility was tested using two mouse models of breast cancer. Deletion of PER3 is directly related to tumor recurrence in patients with estrogen receptor (ER) - positive breast cancers treated with tamoxifen. Low expression of PER3 mRNA is associated with poor prognosis, particularly in a subset of tumors that are ER positive, and either luminal A or ERBB2-positive tumors. Mice deficient in Per3 showed increased susceptibility to breast cancer induced by carcinogen treatment or by overexpression of Erbb2. Disruption of PER3 function may serve as an indicator of probability of tumor recurrence in patients with ER-positive tumors. Further investigations of this pathway may reveal links between deregula...Continue Reading

References

Aug 26, 1998·The EMBO Journal·T TakumiH Okamura
Aug 11, 2000·Molecular and Cellular Biology·L P ShearmanD R Weaver
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Oct 18, 2001·Journal of the National Cancer Institute·E S SchernhammerG A Colditz
Oct 30, 2001·Behavioural Brain Research·Y BenjaminiI Golani
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Oct 24, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M EriguchiY Takeda
Oct 12, 2004·BMC Molecular Biology·Takuro YamamotoToru Takumi
Mar 26, 2005·Carcinogenesis·Shou-Tung ChenJan-Gowth Chang
Aug 9, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sarah P MegdalEva S Schernhammer
Jan 20, 2006·The New England Journal of Medicine·James D Yager, Nancy E Davidson
Apr 6, 2006·Cancer Causes & Control : CCC·Francis Lévi
Feb 10, 2007·Cell·Anindya BagchiAlea A Mills
Mar 10, 2007·Current Biology : CB·Antoine U ViolaDerk-Jan Dijk
May 8, 2007·Cell·Tim Hunt, Paolo Sassone-Corsi
May 12, 2007·Chromosoma·Spencer J Collis, Simon J Boulton
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·S Gery, H P Koeffler
Jan 17, 2009·Sleep Medicine Reviews·Josephine Arendt

❮ Previous
Next ❯

Citations

Jul 4, 2012·Breast Cancer Research and Treatment·Cheryl L Thompson, Li Li
Jul 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Wendy W Hwang-VersluesWen-Hwa Lee
Feb 22, 2012·Cancer Research·Gaofeng XiongRen Xu
Dec 1, 2011·Epigenomics·Charlotte L GeorgeSimon C Biddie
Aug 12, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Pasquale F InnominatoGeorg A Bjarnason
Jun 13, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Olaf NeumannThomas Longerich
Sep 17, 2013·Journal of Surgical Oncology·Theodoros KarantanosDimitrios Pektasidis
Dec 10, 2013·Journal of Cancer Epidemiology·Ali KhawajaCheryl L Thompson
Aug 19, 2015·Nature Cell Biology·Lin YuanLingqiang Zhang
Dec 17, 2014·Oncology Reports·Melannie AlexanderJames R Hébert
Sep 4, 2016·Breast Cancer Research : BCR·Victoria BlakemanCharles H Streuli
Mar 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miji YeomEunsun Jung
Dec 23, 2017·Nature Communications·Hsu-Wen ChaoHitoshi Okamura
Mar 21, 2013·Nature Reviews. Neuroscience·Rafael Tabarés-Seisdedos, John L Rubenstein
Oct 31, 2015·Oncotarget·Cheng-Rong XieZhen-Yu Yin
May 14, 2014·Molecular Medicine Reports·Patricia CoutoLuciana Bastos-Rodrigues
Apr 10, 2015·Molecular Cancer Therapeutics·Lekun FangMong-Hong Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Psychiatry : the Journal of the Association of European Psychiatrists
S DallaspeziaF Benedetti
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Cheng-Ming HsuMing-Yu Yang
Arteriosclerosis, Thrombosis, and Vascular Biology
Hélène Duez, Bart Staels
© 2021 Meta ULC. All rights reserved