Deletion of the UT receptor gene results in the selective loss of urotensin-II contractile activity in aortae isolated from UT receptor knockout mice

British Journal of Pharmacology
David J BehmStephen A Douglas

Abstract

1 Urotensin-II (U-II) is among the most potent mammalian vasoconstrictors identified and may play a role in the aetiology of essential hypertension. Currently, only one mouse U-II receptor (UT) gene has been cloned. It is postulated that this protein is solely responsible for mediating U-II-induced vasoconstriction. 2 This hypothesis has been investigated in the present study, which assessed basal haemodynamics and vascular reactivity to hU-II in wild-type (UT((+/+))) and UT receptor knockout (UT((-/-))) mice. 3 Basal left ventricular end-diastolic and end-systolic volumes/pressures, stroke volumes, mean arterial blood pressures, heart rates, cardiac outputs and ejection fractions in UT((+/+)) mice and in UT((-/-)) mice were similar. 4 Relative to UT((+/+)) mouse isolated thoracic aorta, where hU-II was a potent spasmogen (pEC(50)=8.26+/-0.08) that evoked relatively little vasoconstriction (17+/-2% 60 mM KCl), vessels isolated from UT((-/-)) mice did not respond to hU-II. However, in contrast, the superior mesenteric artery isolated from both the genotypes did not contract in the presence of hU-II. Reactivity to unrelated vasoconstrictors (phenylephrine, endothelin-1, KCl) and endothelium-dependent/independent vasodilator agent...Continue Reading

References

Oct 30, 1992·Biochemical and Biophysical Research Communications·J M ConlonH Vaudry
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S Munro, T Maniatis
Dec 1, 1986·General and Comparative Endocrinology·A GibsonH A Bern
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D PearsonH A Bern
Apr 17, 1995·Biochemical and Biophysical Research Communications·M TalD A Thompson
Jul 25, 1996·Biochemical and Biophysical Research Communications·M E AlfieO A Carretero
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y CoulouarnH Vaudry
Dec 3, 1999·Biochemical and Biophysical Research Communications·Q LiuC T Caskey
Aug 22, 2000·British Journal of Pharmacology·F E BottrillR White
Aug 26, 2000·British Journal of Pharmacology·D W HayS A Douglas
Oct 6, 2000·European Journal of Pharmacology·O Saetrum OpgaardD N Krause
Jan 13, 2001·British Journal of Pharmacology·F D RussellD M O'Brien
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A StirratM R MacLean
Apr 20, 2001·British Journal of Pharmacology·S M GardinerT Bennett
Jul 10, 2001·Psychopharmacology·J GartlonD N Jones
Jul 18, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R A SilvestreJ Marco
Sep 21, 2001·Lancet·K TotsuneO Murakami
Jan 31, 2002·Naunyn-Schmiedeberg's Archives of Pharmacology·Valeria CamardaDomenico Regoli
Jun 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Andre ShenoudaAdel Giaid
Jun 22, 2002·Lancet·Stephen A DouglasAdel Giaid
Sep 10, 2002·Peptides·Yang LuChao-Shu Tang
Sep 21, 2002·Lancet·A Mark RichardsTimothy G Yandle
Oct 17, 2002·British Journal of Pharmacology·Janet J Maguire, Anthony P Davenport
Nov 8, 2002·Journal of Neurochemistry·Catalin M FilipeanuNae J Dun
Nov 26, 2002·Journal of Hepatology·Jörg HellerTilman Sauerbruch
Jan 25, 2003·Journal of Hypertension·Yingzi LinMitsuo Iida

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Citations

Nov 19, 2004·Naunyn-Schmiedeberg's Archives of Pharmacology·Douglas G JohnsStephen A Douglas
Aug 8, 2007·Journal of Anesthesia·John McDonaldDavid G Lambert
May 11, 2005·Cardiovascular Drugs and Therapy·Kwok Leung OngBernard M Y Cheung
Mar 17, 2007·Current Hypertension Reports·Henry Krum, Will Kemp
Apr 23, 2004·Trends in Pharmacological Sciences·Stephen A DouglasDouglas G Johns
Mar 5, 2009·British Journal of Anaesthesia·A D LeonardD G Lambert
Aug 31, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takuya WatanabeTakashi Katagiri
May 25, 2004·Expert Opinion on Investigational Drugs·Sheila A Doggrell
Aug 21, 2010·Peptides·Gregory S HarrisChristopher J Wingard
Mar 30, 2010·Peptides·Diego GuidolinDomenico Ribatti
Jul 9, 2008·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Rajbabu Pakala
Oct 16, 2007·Peptides·Gervaise LoirandPierre Pacaud
Oct 13, 2007·Peptides·Jérôme LeprinceHubert Vaudry
Oct 16, 2007·Peptides·Markus Tölle, Markus van der Giet
Nov 11, 2005·The FEBS Journal·Hans-Peter Nothacker, Stewart Clark
Feb 14, 2012·Experimental Physiology·Ellen J Forty, Nick Ashton
Oct 13, 2004·Peptides·George ThanassoulisAdel Giaid
Oct 13, 2004·Peptides·A Mark Richards, Chris Charles
Oct 7, 2004·Pharmacology & Therapeutics·Fraser D Russell
Nov 24, 2004·Pharmacology & Therapeutics·Torsten SchönebergKatrin Sangkuhl
Dec 20, 2005·Journal of Chemical Neuroanatomy·Johann-Günther EggingerAndré Calas
Jan 7, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Remo GuerriniDomenico Regoli
Dec 31, 2009·Journal of Cardiovascular Pharmacology·Koji KatoKyoichi Mizuno
May 24, 2008·The Journal of Pharmacology and Experimental Therapeutics·Robert N WilletteXiaoping Xu
Jul 28, 2016·Oncotarget·Alexander A GoldbergArnold S Kristof
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jean-Pierre SegainPierre Pacaud

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