Deliberations more than a cut-off HBsAg value for Nuc cessation

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Wen-Juei JengChien-Hung Chen

Abstract

We agree with the conclusion of the systemic review by Liu J et al.(1) that end of treatment (EOT) quantitative HBsAg (qHBsAg) < 100 IU/ml could be a level for stopping nucleos(t)ide analuges therapy. However, we were surprised that: (A), several important off-therapy studies meeting authors' selection criteria were neglected (Chen CH CGH 2015; Hsu YC CGH 2016; Wang CC AJG 2016; online by 2017/12: Tseng CH J Formos Med Assoc 2018). Further, 95 patients in the 2013 study(2) were counted twice as they were included in 691 patients of the 2018 study(3); (B), HBV DNA low detection limit in the included studies varied from 12~1000IU/ml. Relapse rate very likely will be higher in patients with EOT HBV DNA up to 1000IU/ml, hence should not be lumped together. This article is protected by copyright. All rights reserved.

References

Jun 8, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wen-Juei JengYun-Fan Liaw
Jun 16, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Chien-Hung ChenChuan-Mo Lee
Oct 19, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Wen-Juei JengYun-Fan Liaw
Nov 7, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wen-Juei JengYun-Fan Liaw

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Jiaye LiuAiqiang Xu
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Chia-Chi Wang, Jia-Horng Kao
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Tao LiAiqiang Xu
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Jiaye LiuAiqiang Xu
© 2022 Meta ULC. All rights reserved