PMID: 10643650Jan 22, 2000

Delimitation of the time of death by immunohistochemical detection of insulin in pancreatic beta-cells

Forensic Science International : Synergy
F WehnerJ Subke

Abstract

To improve the possibilities to delimitate the time of death after longer laytime, it was examined if this is possible by immunohistochemical insulin detection. The results show that in our examination material, the pancreatic beta-cells of up to 12-day-old corpses produce a positive immunoreaction towards insulin in all cases, whereas none of the corpses older than 30 days show such a reaction. This means that in case of a negative immunoreaction, the time of death can be assumed to lie more than 12 days before the autopsy. The fact that a negative immunoreaction occurs consistently after 30 days leads to the conclusion that when insulin has been stained in a specimen, the death of the respective person must lie a maximum of 29 days earlier, whereby these time-limits may change in considerably different surrounding conditions.

References

Nov 1, 1979·Forensic Science International : Synergy·M SchuckW Spann
Jan 1, 1994·International Journal of Legal Medicine·M CingolaniS D Ferrara

Citations

Jun 8, 2000·Forensic Science International : Synergy·F WehnerJ Subke
Oct 24, 2001·Forensic Science International : Synergy·F WehnerJ Subke
Jan 17, 2002·Forensic Science International : Synergy·F WehnerJ Subke
Jul 5, 2003·Forensic Science International : Synergy·Alberto J Sabucedo, Kenneth G Furton
May 4, 2013·Legal Medicine·Shiwei MaoZhenyuan Wang
Sep 6, 2011·Science & Justice : Journal of the Forensic Science Society·Shiwei MaoZhenyuan Wang
Jun 12, 2009·Legal Medicine·Shogo KasudaKatsuhiko Hatake
Nov 5, 2011·Journal of Anatomy·Ryan Metcalfe, Tony Freemont
Jun 5, 2016·Forensic Science, Medicine, and Pathology·Burkhard Madea
Jul 15, 2016·Forensic Science, Medicine, and Pathology·Joris Meurs
Sep 27, 2005·Forensic Science International : Synergy·D BreitmeierW J Kleemann
Apr 6, 2020·International Journal of Legal Medicine·Stefan PittnerJens Amendt
Mar 14, 2019·International Journal of Legal Medicine·Kyoung-Min ChoiStefan Pittner
Jan 1, 2010·Experimental and Therapeutic Medicine·Kiyoshi KikuchiIkuro Maruyama
Dec 2, 2020·Diagnostics·Angela ZisslerStefan Pittner

Related Concepts

Autolysis
Autopsy
Clothing
Immunocytochemistry
Insulin B Chain
Islets of Langerhans
Livor Mortis
Seasonal Variation
Reproducibility of Results

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