PMID: 10842031Jun 8, 2000

Delimitation of the time of death by immunohistochemical detection of thyroglobulin

Forensic Science International : Synergy
F WehnerJ Subke

Abstract

To improve the possibilities to delimit the time of death after longer laytime it was examined if this is possible by immunohistochemical detection of thyroglobulin. The results show that in our examination material the colloid and the follicular cells of the thyroid glands of up to 5-day-old corpses produce a positive immunoreaction towards thyroglobulin in all cases whereas none of the corpses older than 13 days show such a reaction. This means that in case of a negative immunoreaction the time of death can be assumed to lie more than 6 days before the autopsy. The fact that a negative immunoreaction occurs consistently after 13 days leads to the conclusion that when thyroglobulin has been stained in a specimen, the death of the respective person must lie a maximum of 12 days earlier, whereby these time-limits may change in considerably different surrounding conditions.

References

Nov 1, 1979·Forensic Science International : Synergy·M SchuckW Spann
Jan 1, 1994·International Journal of Legal Medicine·M CingolaniS D Ferrara
Jan 22, 2000·Forensic Science International : Synergy·F WehnerJ Subke

Citations

Oct 24, 2001·Forensic Science International : Synergy·F WehnerJ Subke
Jan 17, 2002·Forensic Science International : Synergy·F WehnerJ Subke
Nov 5, 2011·Journal of Anatomy·Ryan Metcalfe, Tony Freemont
Sep 27, 2005·Forensic Science International : Synergy·D BreitmeierW J Kleemann
Oct 14, 2005·Legal Medicine·Takaki IshikawaHitoshi Maeda
Jun 5, 2016·Forensic Science, Medicine, and Pathology·B Madea
Mar 14, 2019·International Journal of Legal Medicine·Kyoung-Min ChoiStefan Pittner
Dec 2, 2020·Diagnostics·Angela ZisslerStefan Pittner

Related Concepts

Near-Death Experience
Immunocytochemistry
Livor Mortis
Thyroglobulin
Thyroid Gland

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