PMID: 11672961Oct 24, 2001

Delimitation of the time of death by immunohistochemical detection of calcitonin

Forensic Science International : Synergy
F WehnerJ Subke

Abstract

To improve the possibilities of delimitating the time of death after longer laytime it was examined if this is possible by immunohistochemical detection of calcitonin. The results show that in our examination material the c-cells of the thyroid glands of up to 4-day-old corpses produce a positive immunoreaction towards calcitonin in all cases whereas none of the corpses older than 13 days show such a reaction. This means that in the case of a negative immunoreaction the time of death can be assumed to lie >4 days before the autopsy. The fact that a negative immunoreaction occurred consistently after 13 days leads to the conclusion that when calcitonin has been stained in a specimen, the death of the respective person must lie a maximum of 12 days earlier, whereby these time-limits may change in considerably different surrounding conditions.

References

Nov 1, 1979·Forensic Science International : Synergy·M SchuckW Spann
Jan 1, 1983·Endocrine Reviews·E Canalis
Jan 1, 1994·International Journal of Legal Medicine·M CingolaniS D Ferrara
Jan 22, 2000·Forensic Science International : Synergy·F WehnerJ Subke
Jun 8, 2000·Forensic Science International : Synergy·F WehnerJ Subke

Citations

Jan 17, 2002·Forensic Science International : Synergy·F WehnerJ Subke
Nov 5, 2011·Journal of Anatomy·Ryan Metcalfe, Tony Freemont
May 1, 2016·Journal of Forensic and Legal Medicine·S L Belsey, R J Flanagan
Jun 5, 2016·Forensic Science, Medicine, and Pathology·B Madea
Oct 14, 2005·Legal Medicine·Takaki IshikawaHitoshi Maeda
Dec 2, 2020·Diagnostics·Angela ZisslerStefan Pittner

Related Concepts

Ciba 47175-BA
Legal Medicine Discipline
Immunocytochemistry
Livor Mortis
Seasonal Variation
Thyroid Gland

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