Delineation of condition specific Cis- and Trans-acting elements in plant promoters under various Endo- and exogenous stimuli

BMC Genomics
Chi-Nga ChowWen-Chi Chang

Abstract

Transcription factors (TFs) play essential roles during plant development and response to environmental stresses. However, the relationships among transcription factors, cis-acting elements and target gene expression under endo- and exogenous stimuli have not been systematically characterized. Here, we developed a series of bioinformatics analysis methods to infer transcriptional regulation by using numerous gene expression data from abiotic stresses and hormones treatments. After filtering the expression profiles of TF-encoding genes, 291 condition specific transcription factors (CsTFs) were obtained. Differentially expressed genes were then classified into various co-expressed gene groups based on each CsTFs. In the case studies of heat stress and ABA treatment, several known and novel cis-acting elements were identified following our bioinformatics approach. Significantly, a palindromic sequence of heat-responsive elements is recognized, and also obtained from a 3D protein structure of heat-shock protein-DNA complex. Notably, overrepresented 3- and 4-mer motifs in an enriched 8-mer motif could be a core cis-element for a CsTF. In addition, the results suggest DNA binding preferences of the same CsTFs are different according ...Continue Reading

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Methods Mentioned

BETA
immunoprecipitation
ChIP-seq
affinity purification
chip

Software Mentioned

Tomtom
RiceXPro
NASCArrays
ClustalW
JASPAR
Bioconductor
affy package of
WebLogo
Bowtie
RAP

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