Mar 21, 2020

Delineation of Homeostatic Immune Signatures Defining Viremic Non-progression in HIV-1 Infection

Frontiers in Immunology
Amit Kumar SinghVainav Patel

Abstract

Viremic non-progressors (VNPs), a distinct group of HIV-1-infected individuals, exhibit no signs of disease progression and maintain persistently elevated CD4+ T cell counts for several years despite high viral replication. Comprehensive characterization of homeostatic cellular immune signatures in VNPs can provide unique insights into mechanisms responsible for coping with viral pathogenesis as well as identifying strategies for immune restoration under clinically relevant settings such as antiretroviral therapy (ART) failure. We report a novel homeostatic signature in VNPs, the preservation of the central memory CD4+ T cell (CD4+ T CM ) compartment. In addition, CD4+ TCM preservation was supported by ongoing interleukin-7 (IL-7)-mediated thymic repopulation of naive CD4+ T cells leading to intact CD4+ T cell homeostasis in VNPs. Regulatory T cell (Treg) expansion was found to be a function of preserved CD4+ T cell count and CD4+ T cell activation independent of disease status. However, in light of continual depletion of CD4+ T cell count in progressors but not in VNPs, Tregs appear to be involved in lack of disease progression despite high viremia. In addition to these homeostatic mechanisms resisting CD4+ T cell depletion ...Continue Reading

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Mentioned in this Paper

Certified Midwife
Antiretroviral Therapy
CD4 Positive Naive T-Lymphocyte
Cellular Immunity
Signs and Symptoms
Biologic Preservation
Thymus Gland
Cytotoxicity
Cell Growth
Interleukin-4

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