Delineation of the role of platelet-activating factor in the immunoglobulin G2 antibody response

Clinical and Diagnostic Laboratory Immunology
Salma Al-DarmakiS E Barbour

Abstract

Localized aggressive periodontitis (LAgP) is a chronic inflammatory disease characterized by severe destruction of periodontal tissues surrounding the first molars and incisors. LAgP subjects produce large amounts of immunoglobulin G2 (IgG2) antibody against oral pathogens, and this response is inversely correlated with the severity of disease. We previously demonstrated that platelet-activating factor (PAF) is required for optimal IgG2 responses. The present investigation was designed to determine the mechanism of IgG2 induction by PAF. Exogenous PAF acetylhydrolase suppressed approximately 80% of pokeweed mitogen-stimulated IgG2 production, confirming that PAF is essential for optimal responses. PAF-activated leukocytes produced gamma interferon (IFN-gamma), a Th1 cytokine that has been associated with IgG2 responses in previous studies. The monocyte-derived cytokines interleukin-12 (IL-12) and IL-18 are upstream of IFN-gamma production, and IgG2 production was suppressed by neutralizing antibodies against these proteins. In addition, PAF induced monocyte-derived dendritic cells (DC) but not macrophages (MPhi) to secrete IL-12 and IL-18. This observation was interesting because monocyte differentiation in LAgP subjects is ske...Continue Reading

References

Jun 1, 1992·European Journal of Immunology·C CalabresseY Thomas
Jan 1, 1990·Methods in Enzymology·D M StafforiniS M Prescott
Jan 1, 1989·Archives of Oral Biology·K NoguchiS Murota
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D M StafforiniS M Prescott
Aug 1, 1974·Journal of Periodontology·J D Manson, T Lehner
Aug 1, 1971·Journal of Periodontology·P N Baer
Apr 26, 1995·Biochemical and Biophysical Research Communications·R A FranklinE W Gelfand
Apr 1, 1995·Journal of Dental Research·M L GaritoL M McManus
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·J BalsindeE A Dennis
Sep 1, 1993·Cellular Immunology·M S Lin, Y W Chen
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E MüllerM Rola-Pleszczynski
Jul 1, 1993·Journal of Periodontology·M A DanielT E Van Dyke
Jan 1, 1993·The Journal of Allergy and Clinical Immunology·L A SandersB J Zegers
Jan 1, 1996·Advances in Experimental Medicine and Biology·M L KapsenbergA Snijders
Aug 1, 1997·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·P DagenaisM Rola-Pleszczynski
Aug 5, 1998·Journal of Periodontal Research·G E SalviS Offenbacher
Aug 31, 2000·Annual Review of Biochemistry·S M PrescottT M McIntyre
Feb 13, 2001·Journal of Clinical Periodontology·B SiguschE Glockmann
Mar 20, 2002·Shock·Eileen M BulgerRonald V Maier
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Stanford L PengLaurie H Glimcher
May 11, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·L M McManus, R N Pinckard
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stuart G TangyePhilip D Hodgkin
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Salma Al-DarmakiSuzanne E Barbour
Dec 26, 2002·Annual Review of Immunology·Susanne J SzaboLaurie H Glimcher
Jul 31, 2003·Journal of Periodontology·Shigehisa TanakaJohn G Tew

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Citations

Jul 25, 2006·Journal of Dental Research·C W Cutler, R Jotwani
Aug 18, 2010·Marine Drugs·Anne-Laure DeniauAlain B Legrand
Sep 14, 2007·Periodontology 2000·Christopher W Cutler, Yen-Tung A Teng
Dec 15, 2016·Scientific Reports·Marianna M KogaSonia Jancar
Dec 17, 2016·Brazilian Dental Journal·Andressa Lamari ReisAntônio Paulino Ribeiro

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