Delipidated retroviruses as potential autologous therapeutic vaccines--a pilot experiment

Experimental Biology and Medicine
Moiz KitabwallaJames E K Hildreth

Abstract

This pilot experiment in a simian immunodeficiency virus (SIV) chronic infection model aimed at extending our previous findings that vaccination with delipidated SIV resulted in more potent and diversified antiviral responses (1). Macaques chronically infected with SIVmac239 treated with antiretroviral therapy (ART) were vaccinated with autologous delipidated virus via consecutive lymph node targeted immunizations-1, 1 and 10 mug of virus spaced monthly. Results showed all animals had lasting viral load reduction approaching 1 log compared to set-point, and disease delay. Delipidation may enhance processing/ presentation of viral antigen eliciting potent antiviral control even at such late infection stage.

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Methods Mentioned

BETA
FACS
ELISA
FCS
flow cytometry
Enzyme Linked Immunosorbent Assay

Software Mentioned

Cell Quest

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