Delivering anti-cancer drugs with endosomal pH-sensitive anti-cancer liposomes

Biomaterials Science
Gopikrishna MokuArabinda Chaudhuri

Abstract

Numerous prior studies have been reported on the use of pH-sensitive drug carriers such as micelles, liposomes, peptides, polymers, nanoparticles, etc. that are sensitive to the acidic (pH = ∼6.5) microenvironments of tumor tissues. Such systems have been primarily used in the past as effective drug/gene/microRNA carriers for releasing their anti-cancer payloads selectively to tumor cells/tissues. Herein, we report on the development of new liposomal drug carriers prepared from glutamic acid backbone-based cationic amphiphiles containing both endosomal pH-sensitive histidine as well as cellular uptake & solubility enhancing guanidine moieties in their polar head-group regions. The most efficient one among the four presently described endosomal pH-sensitive liposomal drug carriers not only effectively delivers potent anti-cancer drugs (curcumin & paclitaxel) to mouse tumor, but also significantly contributes to inhibiting mouse tumor growth. The findings in the in vitro mechanistic studies are consistent with apoptosis of tumor cells being mediated through increased cell cycle arrest in the G2/M phase. Findings in the FRET assay and in vitro drug release studies conducted with the liposomes of the most efficient pH-sensitive lip...Continue Reading

References

Jun 1, 1996·Nature Biotechnology·V BudkerJ A Wolff
Dec 10, 2002·International Journal of Cancer. Journal International Du Cancer·Weng-Lang YangT S Ravikumar
Mar 5, 2004·Biochimica Et Biophysica Acta·Juanita C SharpeRichard J Youle
Apr 7, 2004·Advanced Drug Delivery Reviews·Sérgio SimõesMaria C Pedroso de Lima
Mar 2, 2006·Pharmacological Reviews·Ikramy A KhalilHideyoshi Harashima
Jun 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hui XiaoGeorge A Orr
Oct 6, 2006·Medicinal Research Reviews·Priya Prakash Karmali, Arabinda Chaudhuri
Apr 19, 2007·Journal of Nanobiotechnology·Savita BishtAnirban Maitra
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·David B RozemaJon A Wolff
Dec 11, 2007·Biochimica Et Biophysica Acta·Barbara T McGroganAmanda McCann
May 8, 2010·Chemical Society Reviews·Ramishetti SrinivasArabinda Chaudhuri
Oct 12, 2011·Journal of the American Chemical Society·Jin-Zhi DuJun Wang
Jul 18, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yali WuZhiyuan Zhong
Aug 29, 2013·Journal of Biomedical Nanotechnology·André Luís Branco de BarrosValbert Nascimento Cardoso
Sep 10, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ann L B SeynhaeveTimo L M Ten Hagen
Dec 7, 2013·Biotechnology Advances·Juan LiuXing-Jie Liang
Jul 9, 2014·Molecular Pharmaceutics·Ramona-Cosmina AdochiteYana K Reshetnyak
Nov 20, 2014·Nature·Christopher J ChengFrank J Slack
Jul 30, 2015·Biomaterials Science·Shahdeep KaurRinti Banerjee

❮ Previous
Next ❯

Citations

Oct 16, 2016·ACS Applied Materials & Interfaces·Shweta SharmaPrabhat Ranjan Mishra
Feb 14, 2017·Biomaterials Science·Qing PeiZhigang Xie
Jul 6, 2017·Chemical Communications : Chem Comm·Parikshit MoitraSantanu Bhattacharya
May 29, 2019·Organic & Biomolecular Chemistry·Abhishek SahaDebasis Manna
Feb 16, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Y Lee, D H Thompson
Jul 10, 2020·Journal of Biomaterials Science. Polymer Edition·Bo LiYanhai Li
Mar 14, 2017·Nutrition and Cancer·Parasuraman Aiya SubramaniVenkata Ramireddy Narala
Dec 17, 2020·International Journal of Nanomedicine·Lanmei LiYumeng Wei
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Rajan SwamiSanyog Jain
Apr 20, 2021·ACS Biomaterials Science & Engineering·Parikshit MoitraSantanu Bhattacharya
Jun 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Emily XuAlexandra S Piotrowski-Daspit
Jan 20, 2021·ACS Biomaterials Science & Engineering·Vijay Sagar MadamsettySudip Mukherjee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis