Delivering drugs to the central nervous system: an overview

Drug Delivery and Translational Research
Patricia I Dickson

Abstract

Developing therapies for the brain is perhaps the greatest challenge facing modern medicine today. While a great many potential therapies show promise in animal models, precious few make it to approval or are even studied in human patients. The particular challenges to the translation of neurotherapeutics to the clinic are many, but a major barrier is difficulty in delivering therapeutics into the brain. The goal of this workshop was to present ways to deliver therapeutics to the brain, including the limitations of each method, and describe ways to track their delivery, safety, and efficacy. Solving the problem of delivery will aid translation of therapeutics for patients suffering from neurodegeneration and other disorders of the brain.

References

Feb 15, 1992·American Journal of Medical Genetics·R M TaylorG J Stewart
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·R H BoboE H Oldfield
Apr 15, 1993·American Journal of Medical Genetics·C B WhitleyJ H Kersey
Apr 17, 1998·The New England Journal of Medicine·W KrivitL A Lockman
Feb 5, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·U DunderI Mononen
Mar 29, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·W A FrisellaM S Sands
Aug 16, 2002·Bone Marrow Transplantation·I RanaG De Rossi
Oct 23, 2002·Pediatric Transplantation·Maurizio CanigliaGiulio De Rossi
Sep 17, 2003·European Journal of Anaesthesiology·S BrillA Fisher
Jul 23, 2004·Human Molecular Genetics·Diego Prieto RocesKurt von Figura
Aug 3, 2004·Nature Reviews. Drug Discovery·Ismail Kola, John Landis
May 20, 2005·The New England Journal of Medicine·Maria L EscolarJoanne Kurtzberg
Sep 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Carole VoglerWilliam S Sly
Jan 6, 2006·Annals of the New York Academy of Sciences·James M ProvenzaleJoanne Kurtzberg
Dec 15, 2006·Molecular Genetics and Metabolism·Kim M HemsleyJohn J Hopwood
Feb 27, 2007·Molecular Genetics and Metabolism·Patricia DicksonEmil Kakkis
Apr 4, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wing C LeeChristopher B Eckman
Aug 8, 2007·Biotechnology and Bioengineering·Ruben J BoadoWilliam M Pardridge
Aug 11, 2007·Lancet Neurology·Marc C PattersonJames E Wraith
Sep 25, 2007·Journal of Child Neurology·Maria GörgAlfried Kohlschütter
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey H GrubbWilliam S Sly
Mar 26, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Michael ChangBeverly L Davidson
Jun 19, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Silvia MuroVladimir R Muzykantov
Jul 22, 2008·Experimental Neurology·Dolan SondhiRonald G Crystal
Dec 11, 2008·Annals of Neurology·Tyler Mark PiersonGihan I Tennekoon

❮ Previous
Next ❯

Citations

Jan 16, 2013·Molecular Pharmaceutics·Mikhail I PapisovKimberley S Gannon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Mahlon R Delong, Stewart A Factor
NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics
William M Pardridge
Journal of Neurotrauma
J T PovlishockT K McIntosh
© 2021 Meta ULC. All rights reserved