Delivering non-hormonal contraceptives to men: advances and obstacles

Trends in Biotechnology
Dolores D Mruk, C Yan Cheng

Abstract

There have been major advances in male contraceptive research during the past two decades. However, for a contraceptive to be used by men, its safety requires more stringent scrutiny than therapeutic compounds for treatment of illnesses because the contraceptives will be used by healthy individuals for an extended period of time, perhaps decades. A wide margin is therefore required between the effective dose range and doses that cause toxicity. It might be preferable that a male contraceptive, in particular a non-hormone-based compound, is delivered specifically and/or directly to the testis and has a rapid metabolic clearance rate, reducing the length of exposure in the liver and kidney. In this article, we highlight the latest developments regarding contraceptive delivery to men and with the aim of providing useful information for investigators in future studies.

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Citations

Feb 11, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Ka-Wai MokC Yan Cheng
Nov 1, 2011·Pharmacological Reviews·C Yan Cheng, Dolores D Mruk
Jul 23, 2009·Critical Reviews in Biochemistry and Molecular Biology·C Yan Cheng, Dolores D Mruk
Jan 24, 2013·Critical Reviews in Biochemistry and Molecular Biology·Wenhui SuC Yan Cheng
Jul 26, 2013·Spermatogenesis·Marine BaptissartDavid H Volle
Feb 10, 2012·Spermatogenesis·Yan-Ho ChengC Yan Cheng
Apr 15, 2014·Seminars in Cell & Developmental Biology·H T WanC Yan Cheng
Oct 10, 2009·International Review of Cell and Molecular Biology·Elissa W P Wong, C Yan Cheng
Nov 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Linlin SuC Yan Cheng
Jun 24, 2010·Nature Reviews. Endocrinology·C Yan Cheng, Dolores D Mruk
Sep 12, 2015·Endocrine Reviews·Dolores D Mruk, C Yan Cheng
Nov 29, 2012·Expert Review of Pharmacoeconomics & Outcomes Research·Emily Dorman, David Bishai
May 15, 2013·Asian Journal of Andrology·Xiaojing QianC Yan Cheng
Sep 15, 2012·Journal of Cell Science·Xiang XiaoDolores D Mruk

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