Delivery and safety of inhaled interferon-γ in idiopathic pulmonary fibrosis

Journal of Aerosol Medicine and Pulmonary Drug Delivery
Keith T DiazR Condos

Abstract

Inhaled interferon-γ aerosol (aINF-γ) may be effective treatment for idiopathic pulmonary fibrosis (IPF). We evaluated safety and delivery of aIFN-γ (100 μg 3 times/week) in 10 IPF patients using the I-neb (Philips Respironics, Parsippany, NJ). IFN-γ activity in the aerosol was confirmed by viral inhibition. Ten patients with an average age of 68 diagnosed with IPF (American Thoracic Society/European Respiratory Society consensus guidelines) were enrolled. In vivo deposition was measured via a gamma camera. The nebulizer recorded patient adherence to therapy. Pulmonary function tests [PFTs, forced vital capacity (FVC), total lung capacity (TLC), diffusing capacity for carbon monoxide (DLCO)] and the 6-min walk test were measured at baseline, and every 12-14 weeks for 80 weeks. Bronchoalveolar lavage (BAL) of the middle lobe was performed at baseline and 28 weeks. BAL and plasma samples were analyzed for chemokines and cytokines, including INF-γ. All 10 patients tolerated 80 weeks of inhaled IFN-γ well, with no systemic side effects. True adherence with aerosol treatment averaged 96.7 ± 4.81% (± SEM). In vivo lung deposition averaged 65.4 ± 4.8μg and oropharyngeal deposition 12.6 ± 3.0 μg. BAL IFN-γ increased 60-fold and profibr...Continue Reading

References

May 1, 1992·The American Review of Respiratory Disease·T G O'RiordanG C Smaldone
Apr 1, 1987·Journal of Applied Physiology·W D Bennett, G C Smaldone
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·D A SchwartzG W Hunninghake
Apr 1, 1997·American Journal of Respiratory Cell and Molecular Biology·M Gharaee-Kermani, S H Phan
May 1, 1997·Chest·M McPeckG C Smaldone
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·J A BjorakerK P Offord
Nov 21, 1998·Journal of Leukocyte Biology·M Gharaee-KermaniS H Phan
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·W W DouglasD R Schroeder
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K F HoffmannT A Wynn
Nov 7, 2000·Journal of Pharmaceutical Sciences·S Porter
Mar 23, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·G C Smaldone
Apr 12, 2001·Journal of Clinical Epidemiology·R Bender, S Lange
Oct 24, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Kurt NikanderNicolas Cobos
Nov 14, 2003·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Aleksandra Wodnar-Filipowicz
Jan 9, 2004·The New England Journal of Medicine·Ganesh RaghuUNKNOWN Idiopathic Pulmonary Fibrosis Study Group
Feb 24, 2004·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Sanjay SangwanGerald C Smaldone
Mar 27, 2004·American Journal of Respiratory and Critical Care Medicine·Robert M StrieterUNKNOWN Idiopathic Pulmonary Fibrosis Biomarkers Study Group
Aug 3, 2004·Nature Reviews. Immunology·Thomas A Wynn
Jan 25, 2005·American Journal of Respiratory and Critical Care Medicine·Arata AzumaShoji Kudoh
May 13, 2005·The New England Journal of Medicine·L Terry SpencerUNKNOWN Transgenic Human Alpha 1-Antitrypsin Study Group
Nov 25, 2005·The New England Journal of Medicine·Maurits DemedtsUNKNOWN IFIGENIA Study Group
Apr 12, 2008·Proceedings of the American Thoracic Society·Robert M Strieter
Aug 2, 2008·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuSaeed Fatenejad
Apr 28, 2009·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Mario Solomita, Gerald C Smaldone
Nov 7, 2009·Chest·Robert M Strieter, Borna Mehrad
Apr 14, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Kurt NikanderGlyn Taylor
May 27, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Shibu Skaria, Gerald C Smaldone
Oct 12, 2010·American Journal of Respiratory and Critical Care Medicine·Brett LeyTalmadge E King
Jun 3, 2011·Archives of Pathology & Laboratory Medicine·Robert J HomerErica Herzog
Jul 6, 2011·The Journal of Experimental Medicine·Thomas A Wynn

❮ Previous
Next ❯

Citations

Aug 7, 2013·Respiratory Research·Bruno CrestaniArnaud Mailleux
Jun 25, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Zhuang Ma, Wenwu Sun
Aug 29, 2013·Future Oncology·Paul ZarogoulidisKonstantinos Zarogoulidis
Mar 26, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sebastian HertelGerhard Winter
Aug 12, 2014·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Rex B Sagalla, Gerald C Smaldone
Apr 29, 2014·Expert Opinion on Investigational Drugs·Sushmita ChakrabortyAbhijit Ray
Jan 24, 2015·Annals of Medicine·Bashar S StaitiehSrihari Veeraraghavan
Dec 23, 2015·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Virginia NorrisMalcolm Boyce
Sep 4, 2015·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Timothy FusiakRany Condos
Sep 6, 2014·Journal of Aerosol Medicine and Pulmonary Drug Delivery·P Worth LongestMichael Hindle
Mar 19, 2013·International Journal of Pharmaceutics·Flore DepreterKarim Amighi
Feb 27, 2016·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Dimitrios KikidisOmar S Usmani
Dec 16, 2016·Drug Development and Industrial Pharmacy·Stefano GiovagnoliMaurizio Ricci
May 5, 2017·Respiration; International Review of Thoracic Diseases·Daniele MagniniLuca Richeldi
Apr 20, 2018·American Journal of Respiratory and Critical Care Medicine·Zheng DengKefang Lai
Feb 8, 2018·Respiratory Research·Omar S UsmaniToby M Maher
Dec 20, 2019·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Joshua Samuel, Gerald C Smaldone
Sep 26, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aravind T ReddyRaju C Reddy
Apr 5, 2019·Respiratory Research·Louise SweeneyRonan MacLoughlin
Dec 19, 2017·Micromachines·Chen S TsaiGerald C Smaldone
Sep 29, 2020·Frontiers in Bioengineering and Biotechnology·Sandrine Le GuellecLaurent Plantier
Aug 8, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Yet H KhorAnne E Holland
Apr 15, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eleonore Fröhlich, Sharareh Salar-Behzadi

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage
lavage
ELISA
Protein Assay
biopsy

Clinical Trials Mentioned

NCT00563212

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.