Delivery Considerations of Highly Viscous Polymeric Fluids Mimicking Concentrated Biopharmaceuticals: Assessment of Injectability via Measurement of Total Work Done "WT "

AAPS PharmSciTech
Qiangnan ZhangReza Fassihi

Abstract

An account is given of the recent development of the highly viscous complex biopharmaceuticals in relation to syringeability and injectability. The specific objective of this study is to establish a convenient method to examine problem of the injectability for the needle-syringe-formulation system when complex formulations with diverse viscosities are used. This work presents the inter-relationship between needle size, syringe volume, viscosity, and injectability of polymeric solutions having typical viscosities encountered in concentrated biologics, by applying a constant probe crosshead speed on the plunger-syringe needle assembly and continuously recording the force-distance profiles. A computerized texture analyzer was used to accurately capture, display, and store force, displacement, and time data. The force-distance curve and area under the curve are determined, and total work done for complete extrusion of the syringe content was calculated automatically by applying an established Matlab program. Various concentrations (i.e., 0.5-4% w/v of polymeric fluids/dispersions) of polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) with viscosity ranges of 5-100 cP mimicking concentrated monoclonal antibody solutio...Continue Reading

References

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Citations

Apr 29, 2020·The Journal of Pharmacy and Pharmacology·Qiangnan Zhang, Reza Fassihi
Dec 29, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Prashant AgarwalDarren L Reid
Jan 12, 2021·Applied Physics Reviews·Liqun NingVahid Serpooshan
Feb 4, 2021·Biomicrofluidics·Magalí Mercuri, David Fernandez Rivas
Apr 4, 2021·International Journal of Molecular Sciences·Pakama MahlumbaYahya E Choonara
Oct 1, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Cloé L EspositoV Gaëlle Roullin
Nov 23, 2021·Therapeutic Delivery·Shreshtha DashAlekha K Dash

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Methods Mentioned

BETA
rheology

Software Mentioned

Matlab
Matlab code

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