Delivery of a Salmonella Typhi exotoxin from a host intracellular compartment

Cell Host & Microbe
Stefania SpanòJorge E Galán

Abstract

Salmonella Typhi, an exclusive human pathogen and the cause of typhoid fever, expresses a functional cytolethal distending toxin for which only the active subunit, CdtB, has been identified. Here, we show that PltA and PltB, which are encoded in the same pathogenicity islet as cdtB, associate with CdtB to form a multipartite toxin. PltA and PltB are homologs of components of the pertussis toxin, including its ADP-ribosyl transferase subunit. We also show that PltA and PltB are required for the delivery of CdtB from an intracellular compartment to target cells via autocrine and paracrine pathways. We hypothesize that this toxin, which we have named "typhoid toxin," and its delivery mechanism may contribute to S. Typhi's unique virulence properties.

References

Feb 6, 2002·Trends in Microbiology·Robert A EdwardsStanley R Maloy
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Citations

Nov 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Stefania SpanòJorge E Galán
Apr 14, 2010·Infection and Immunity·Helene L Andrews-PolymenisFerric C Fang
Jan 16, 2013·Infection and Immunity·Mariela G Del GiudiceCecilia Czibener
Feb 18, 2014·Acta Crystallographica. Section D, Biological Crystallography·Amanda C KohlerC Erec Stebbins
Sep 11, 2014·Annual Review of Microbiology·Gordon Dougan, Stephen Baker
Oct 19, 2010·Cell Host & Microbe·Jeongmin SongJorge E Galán
Aug 14, 2015·Biomolecules·Francesca Grasso, Teresa Frisan
Aug 25, 2015·Biochimica Et Biophysica Acta·Teresa Frisan
Feb 5, 2008·Current Opinion in Microbiology·Stefania Spanò, Jorge E Galán
Sep 25, 2015·Cellular Microbiology·Cecilia CzibenerJuan Esteban Ugalde
May 21, 2008·Cellular Microbiology·Zhongming GeJames G Fox
Jun 25, 2014·Cellular Microbiology·Stefania Spanò
Nov 5, 2015·Pathogens and Disease·Francesca RosadiAlessia Fabbri
Jul 25, 2015·Gut Pathogens·Lorraine D Rodriguez-RiveraMartin Wiedmann
Jan 15, 2008·Cell Host & Microbe·Mirko Bischofberger, F Gisou van der Goot
Sep 17, 2013·Cell Host & Microbe·Racquel Kim Sherwood, Craig R Roy
Jan 3, 2009·Biochimica Et Biophysica Acta·Lina GuerraKen Teter
Mar 10, 2015·Nature Reviews. Microbiology·Doris L LaRockSamuel I Miller
Mar 21, 2012·FEMS Microbiology Letters·Cintia SánchezViviana C Lepek
May 26, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jorge E Galán
Jul 16, 2014·Nature Reviews. Microbiology·Nathan C SimonJoseph T Barbieri
Sep 1, 2017·International Journal of Molecular Sciences·Enea Gino Di DomenicoFabrizio Ensoli

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