Delivery of fluorescent-labeled cyclodextrin by liposomes: role of transferrin modification and phosphatidylcholine composition

Journal of Liposome Research
Jun ChenXi-Xiong Yang

Abstract

Drug-in-CD-in-liposome (DCL) systems which encapsulate the drug/CD inclusion complexes into inner aqueous phase of liposomes have been applied as a novel strategy to improve efficacy of lipophilic antitumor drugs. The aim of this work was to assess the role of transferrin (Tf) modification and phosphatidylcholine (PC) composition on the properties of liposomes containing hydroxypropyl-β-cyclodextrin (HP-β-CD). Fluorescence dye, FITC, was conjugated with HP-β-CD to facilitate the analysis. The resulting FITC-HP-β-CD was further encapsulated into liposomes and then the liposomes were modified with Tf. The FITC-HP-β-CD-loaded liposomes with different PC compositions were compared in terms of particle size, zeta potential, FITC content, FITC-HP-β-CD leakage, phase transition temperature (Tm) and cellular uptake. The apparent partition coefficient values of different PCs were also determined. Compared to PEGylated liposomes, FITC-HP-β-CD-loaded liposomes modified with Tf had been proved to significantly increase vesicle stability and specific cellular uptake. Moreover, PC composition affected the properties of liposomes. Soybean phosphatidylcholine (SPC) liposomes modified with Tf were found to be more easily internalized into tumor...Continue Reading

References

Jan 1, 1994·Journal of Drug Targeting·B McCormack, G Gregoriadis
Dec 29, 2000·Cancer Chemotherapy and Pharmacology·M J McKeageB C Baguley
Nov 15, 2006·International Journal of Pharmaceutics·Panayiota HatziSophia G Antimisiaris
Dec 11, 2007·Biochimica Et Biophysica Acta·Mojca Podlesnik BesenicarGregor Anderluh
Oct 9, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Minghuang HongYuanying Pei
May 12, 2009·International Journal of Pharmaceutics·XueMing LiQiNeng Ping
Mar 12, 2010·Fish & Shellfish Immunology·Mariola A DietrichAndrzej Ciereszko
Aug 31, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·S DadashzadehA M Vali
Mar 1, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Minyan WeiChuanbin Wu
Mar 27, 2012·Current Drug Metabolism·Shuai QianZhong Zuo
Sep 11, 2012·International Journal of Pharmaceutics·Jolanda M van den HovenBastiaan Nuijen
Oct 6, 2012·Advanced Drug Delivery Reviews·Theresa M Allen, Pieter R Cullis
May 16, 2013·Advanced Drug Delivery Reviews·Jianxiang Zhang, Peter X Ma
Sep 21, 2013·Expert Opinion on Drug Delivery·Conchita Tros de Ilarduya, Nejat Düzgüneş
Feb 5, 2014·Expert Opinion on Drug Delivery·Jun ChenXi-Xiong Yang
Oct 1, 2014·International Journal of Pharmaceutics·Ahmed H MatloobSophia G Antimisiaris
Oct 12, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Xiu-Feng ZhangHong-Bo Chen
Jun 9, 2015·Carbohydrate Polymers·Riham GharibLizette Auezova

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