Delivery of ivermectin by injectable microspheres

Journal of Economic Entomology
J A MillerJ M Pound

Abstract

A bioabsorbable, injectable microsphere formulation containing ivermectin in poly-(lactide-co-glycolide) copolymer (PLA/PGA) was developed to provide long-lasting delivery of the drug for control of livestock pests. A solvent-evaporation technique was used to produce the spherical beads containing approximately 30% ivermectin and ranging in size from 25-250 microns. The pattern of delivery of the drug into the blood stream of Spanish goats was characterized for a 50:50 PLA/PGA, a 90:10 PLA/PGA copolymer formulation, and a PLA monomer formulation. When the 50:50 PLA/PGA formulation was used in cattle at the rate of 2 mg (AI)/kg body weight, 2 peaks of 45-50 ppb of ivermectin in serum were observed. The 1st peak was at approximately 1 wk after injection and the 2nd peak, which was broader than the 1st, occurred at approximately 6-7 wk after injection. Percentage of inhibition of estimated larvae for the lone star tick, Amblyomma americanum (L.), placed on treated cattle was 100% for the first 8 wk after injection and was 75, 57, 46 and 44% for wk 9, 10, 11, and 12, respectively. The treatment provided 98-100% control of larval horn flies, Haematobia irritans (L.), in the manure of treated cattle for 10 wk. The bioassay results ag...Continue Reading

Citations

May 22, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gökhan EraslanSule Altinordulu
Aug 29, 2013·Journal of Veterinary Pharmacology and Therapeutics·J M BermudezS Palma
Jun 12, 2004·Advanced Drug Delivery Reviews·Natalie J MedlicottTodd P Foster
Jun 12, 2004·Advanced Drug Delivery Reviews·Gesine WinzenburgThomas Kissel
Jan 14, 2021·Journal of Veterinary Pharmacology and Therapeutics·Salah Uddin AhmadJiyu Zhang
Apr 9, 2002·The Veterinary Record·J A JarvinenD D Oehler

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