Delivery of magnetic micro/nanoparticles and magnetic-based drug/cargo into arterial flow for targeted therapy

Drug Delivery
Mohammad K D ManshadiAmir Sanati-Nezhad

Abstract

Magnetic drug targeting (MDT) and magnetic-based drug/cargo delivery are emerging treatment methods which attracting the attention of many researchers for curing different cancers and artery diseases such as atherosclerosis. Herein, computational studies are accomplished by utilizing magnetic approaches for cancer and artery atherosclerosis drug delivery, including nanomagnetic drug delivery and magnetic-based drug/cargo delivery. For the first time, the four-layer structural model of the artery tissue and its porosity parameters are modeled in this study which enables the interaction of particles with the tissue walls in blood flow. The effects of parameters, including magnetic field strength (MFS), magnet size, particle size, the initial position of particles, and the relative magnetic permeability of particles, on the efficacy of MDT through the artery walls are characterized. The magnetic particle penetration into artery layers and fibrous cap (the covering layer over the inflamed part of the artery) is further simulated. The MDT in healthy and diseased arteries demonstrates that some of the particles stuck in these tissues due to the collision of particles or blood flow deviation in the vicinity of the inflamed part of the...Continue Reading

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Citations

Jul 9, 2020·Biomaterials Science·Shima Masoudi AsilMahesh Narayan
Feb 26, 2019·Drug Delivery·Mohammad K D ManshadiAmir Sanati-Nezhad
Sep 14, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mahsa SaadatAmir Sanati-Nezhad
Apr 4, 2021·Journal of Biomedical Materials Research. Part a·Yana G ToropovaKamil G Gareev
Apr 13, 2021·Biosensors & Bioelectronics·Mehdi MohammadiAmir Sanati-Nezhad
Apr 16, 2021·International Journal of Biological Macromolecules·Thi Mai Thien VoJunghwan Oh
May 21, 2021·Nanoscale Research Letters·Zhongyang YuKaiwen Hu
Jun 4, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xuexin LiZehuan Liao
Sep 1, 2021·Computer Methods and Programs in Biomedicine·Max C LindemannIoana Slabu
Oct 12, 2021·Nanotechnology·Bivas RanaAnjan Barman
Jan 25, 2022·Journal of Mathematical Biology·Ebrahim Azhdari, Jahed Naghipoor
Sep 3, 2020·Combinatorial Chemistry & High Throughput Screening·Mustafa ÇelebierSacide Altınöz

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