Delivery of proteins to CNS as seen and measured by positron emission tomography

Drug Delivery and Translational Research
Mikhail PapisovC A Gillooly

Abstract

Presently, there are no effective treatments for several diseases involving the central nervous system (CNS). While several novel molecular approaches are being developed, many of them require delivery of macromolecular or supramolecular agents to the CNS tissues protected by the blood-brain and blood-arachnoid barriers. A variety of approaches that are being developed for overcoming or bypassing the barriers are based on complex transfer processes. The delivery of biopharmaceuticals and other macromolecules and particulates to the CNS, especially through the leptomeningeal (intrathecal) route, includes a variety of stages, such as leptomeningeal propagation, drainage to the systemic circulation, and penetration into the CNS. The investigation of complex pharmacokinetics that includes convective, as well as diffusional and active transfer processes, greatly benefit from real-time non-invasive in vivo monitoring of the drug transport. Pharmacological positron emission tomography (PET) imaging, which enables such monitoring, plays an increasingly significant role in drug delivery and biopharmacology. PET is a powerful tool for quantitative in vivo tracking of molecules labeled with positron-emitting radionuclides. The high sensit...Continue Reading

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Citations

Jun 1, 2012·Drug Delivery and Translational Research·Mikhail I PapisovC A Gillooly
Jun 24, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiang YiAlexander V Kabanov
Jan 16, 2013·Molecular Pharmaceutics·Mikhail I PapisovKimberley S Gannon
Nov 9, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chandra Mushti, Mikhail I Papisov I Papisov
Jun 14, 2019·Frontiers in Neuroscience·Beata DurcanovaMikhail Papisov
Mar 7, 2020·Advanced Drug Delivery Reviews·M J FowlerR W Sirianni
Mar 12, 2021·Advanced Drug Delivery Reviews·Ghazal Naseri KouzehgaraniDidier R Lefebvre
May 4, 2021·Frontiers in Neuroscience·Vasily BelovMikhail Papisov
Aug 31, 2021·Molecular Pharmaceutics·Kelsey R PflepsenCarolyn A Fairbanks

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