PMID: 8951688Jan 1, 1996Paper

Delivery of systemic regular insulin via the ocular route in dogs

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
R V Morgan, M A Huntzicker

Abstract

Regular porcine insulin was administered as eye drops to eight healthy, euglycemic dogs. Insulin was applied alone and in combination with six different permeation enhancers. Serum glucose and insulin were monitored for four hours following the eye drops. Significant changes in serum glucose and/or insulin occurred when the insulin was administered with 0.5% saponin, 0.5% and 1% BL-9, 0.5% and 1% dodecylmaltoside, and 0.5% and 1% tetradecylmaltoside. Insulin delivered alone and in the presence of 0.5% Brij-78 and 0.5% fusidic acid did not significantly alter glucose and/or insulin concentrations. Solutions containing 0.5% saponin induced signs of ocular irritation for approximately 5 minutes. Transient blinking (1-5 mins.) was encountered with solutions containing 1% BL-9, 1% dodecylmaltoside, and 1% tetradecylmaltoside. No ocular signs occurred with the administration of insulin alone or with 0.5% solutions of Brij-78, fusidic acid, BL-9, dodecylmaltoside, and tetradecylmaltoside. This study demonstrated that short-acting insulin is systemically absorbed in dogs via the ocular route when applied with certain emulsants.

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Citations

Mar 19, 2002·International Journal of Pharmaceutics·Yung-Chi LeeSamuel H Yalkowsky
Jun 17, 1999·International Journal of Pharmaceutics·Y C Lee, S H Yalkowsky
Aug 26, 1999·International Journal of Pharmaceutics·Y C Lee, S H Yalkowsky
Oct 21, 1999·International Journal of Pharmaceutics·Y Lee, S H Yalkowsky
Jan 26, 2011·Journal of Young Pharmacists : JYP·Ga KurianJ Paddikkala
Jul 7, 2007·Journal of Drug Targeting·Akhlesh K JainPrakash V Diwan
Nov 7, 2009·Journal of Pharmaceutical Sciences·Yahya E ChoonaraLisa C du Toit
Jan 10, 1998·Journal of Pharmaceutical Sciences·Y C LeeS H Yalkowsky
Nov 30, 2006·Diabetes & Metabolism·V Lassmann-Vague, D Raccah
Sep 21, 2007·Advanced Drug Delivery Reviews·El-Sayed KhafagyKozo Takayama

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Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
R V Morgan
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