PMID: 9537727Apr 16, 1998Paper

Delmopinol hydrochloride- and chlorhexidine digluconate-induced precipitation of salivary proteins of different molecular weights

Acta Odontologica Scandinavica
L B Freitas-FernandesP O Glantz

Abstract

Gel electrophoresis was used to analyze precipitates formed of delmopinol hydrochloride or chlorhexidine digluconate mixed with unstimulated whole saliva samples from five test subjects. Final concentrations of delmopinol (6.4 mM) or chlorhexidine (6.4 mM, 2.2 mM) mixed with whole saliva were incubated for 10 min at 37 degrees C. The precipitates were pelleted by centrifugation and resuspended to a similar protein density. The protein patterns in the pellets were analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis, using 12.3% gels. The amount of pellet protein was determined by densitometry in four molecular weight ranges (10-21.5, 21.5-26, 26-45, and 45-300). The results indicated that high molecular weight (45-300) proteins dominated in the precipitate and that 2.2 mM chlorlhexidine precipitated more salivary protein than 6.4 mM. At equimolar concentration (6.4 mM) delmopinol precipitated more high molecular weight salivary proteins than chlorhexidine.

References

Jan 1, 1989·Archives of Oral Biology·I Al-Hashimi, M J Levine
Jan 1, 1989·Journal of Dental Research·K Minaguchi, A Bennick
Jan 1, 1987·Archives of Oral Biology·S J FisherP A Murray
Jan 1, 1970·Journal of Periodontal Research·G RöllaC R Schiott
Jul 1, 1968·The Journal of Pharmacy and Pharmacology·D D Heard, R W Ashworth
Jun 15, 1983·European Journal of Biochemistry·T Ericson, J Rundegren

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Citations

Aug 17, 2006·European Journal of Oral Sciences·Andrew JoinerThomas Arnebrant
Mar 18, 2021·Brazilian Oral Research·Tatiana Kelly da Silva FidalgoAna Paula Valente

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