Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cells

Cytotechnology
Gakuro HaradaYoshinori Katakura

Abstract

Delphinidin is an anthocyanidin commonly found in various fruits and vegetables. Delphinidin has been known to possess many functions, such as an antioxidant, and anti-inflammatory, anti-cancer and anti-muscular atrophy agent. In this study, we attempted to evaluate the effects of delphinidin on lipid accumulation in hepatocytes. The results showed that palmitic acid (PA)-induced cellular senescence in HepG2 cells and reduced the expression of SMARCD1, which is known to regulate senescence-associated lipid accumulation in hepatocytes. However, delphinidin-3-glucoside (D3 g) suppressed PA-induced senescence and reversed the expression of SMARCD1 to the level of untreated HepG2 cells. Consequently, D3 g inhibited PA-induced lipid accumulation through the restoration of the expression of SMARCD1 and fatty acid oxidation genes. Taken together, our results suggest that D3 g suppresses the lipid accumulation induced by hepatocyte senescence.

References

Mar 13, 2012·Methods : a Companion to Methods in Enzymology·Miyako UdonoYoshinori Katakura
Apr 30, 2016·Nutrition & Metabolism·Ping ZhangFeiruo Huang
Dec 22, 2016·Journal of Agricultural and Food Chemistry·Motoki MurataHirofumi Tachibana
Sep 5, 2017·Npj Aging and Mechanisms of Disease·Chisato InoueYoshinori Katakura
Dec 30, 2017·Experimental and Therapeutic Medicine·Cheng-Hu WangKun-Peng Li

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Citations

Jun 14, 2019·Frontiers in Plant Science·Georgianna K OguisDavid J Craik
May 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miey ParkHae-Jeung Lee
Jun 9, 2020·Journal of Diabetes Research·Lunan ZhaoGarry X Shen
Sep 27, 2019·Journal of Agricultural and Food Chemistry·Zhixi ChenLonghuo Wu
Nov 17, 2021·Critical Reviews in Food Science and Nutrition·Mina HomayoonfalBahman Yousefi

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