delta 9-Tetrahydrocannabinol increases activity of tyrosine hydroxylase in cultured fetal mesencephalic neurons

Journal of Molecular Neuroscience : MN
Mariluz HernandezJ J Fernández-Ruiz

Abstract

The exposure of pregnant rats to delta 9-tetrahydrocannabinol (delta 9-THC), the main psychoactive constituent of Cannabis sativa, during gestation and lactation, affects the gene expression and the activity of tyrosine hydroxylase (TH) in the brain of their offspring, measured at fetal and early postnatal ages, when the expression of this enzyme plays an important role in neural development. In the present article, we have examined whether delta 9-THC is able to affect TH activity in cultured mesencephalic neurons obtained from fetuses at gestational d 14. Thus, TH activity increased approximately twofold in cells obtained from naive fetuses when exposed for 24 h to medium containing delta 9-THC. In addition, TH activity was also approx twofold higher in cells obtained from fetuses exposed daily to delta 9-THC from d 5 of gestation than in cells obtained from control fetuses, when both were exposed to basal media. This effect of delta 9-THC on TH activity seems to be produced via the activation to cannabinoid receptors, in particular the CB1 subtype, which would presumably be located in these cells. This is because the exposure to medium containing both delta 9-THC and SR141716A, a specific antagonist for CB1 receptors, abolis...Continue Reading

References

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Citations

Nov 17, 2004·Neurotoxicity Research·Javier Fernández-RuizJosé A Ramos
Jul 2, 2009·European Archives of Psychiatry and Clinical Neuroscience·Didier Jutras-AswadYasmin L Hurd
Aug 26, 1999·Life Sciences·J J Fernández-RuizJ A Ramos
Jan 13, 2000·Trends in Neurosciences·J Fernández-RuizJ A Ramos
Apr 15, 2010·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Sahoo SaddichhaChristoday Raja Jayant Khess
Jun 28, 2003·Neurotoxicity Research·José A RamosJavier Fernández-Ruiz
Feb 12, 2004·Journal of Psychopharmacology·Maria C Jockers-ScherüblRainer Hellweg
Aug 10, 2002·The Australian and New Zealand Journal of Psychiatry·Wai-kwong TangRichard Kay
Mar 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Patrik RoserWolfram Kawohl
Jun 22, 2000·The Medical Journal of Australia·D R McKay, C C Tennant
Aug 16, 2005·Brain Research. Developmental Brain Research·Mauro LeonelliAndréa S Torrão

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