PMID: 1208619Sep 1, 1975Paper

Delta 9-tetrahydrocannabinol produced discrimination in pigeons

Pharmacology, Biochemistry, and Behavior
B G HenrikssonT U Järbe

Abstract

In an operant situation pigeons learned to peck one response key 90 min after an injection of 0.25mg/kg delta9-tetrahydrocannabinol (delta9-THC) and another key when trained nondrugged. When tested with doses of delta9-THC lwer than the training dose the birds disciminated 0.20 mg/kg of the drug from the nondrugged state but not 0.15 mg/kg or lower doses. The animals were able to discriminate the drug state from the nondrugged 180 min but not 360 min after the injection At a shorter interval (45 min) both drug and nondrug responding appeared. Cannabinol and cannabidiol (4.0 - 8.0 mg/kg) did not elicit any drug responses, nor did pentobarbital, ditran or amphetamine. Tests with LSD resulted in both drug and nondrug responding. When administering noncannabinoid drugs in combination with delta9-THC 0.15 mg/kg the birds responded at the key associated with the drug state, suggesting interactional effects.

References

Mar 9, 1974·Psychopharmacologia·D P FerraroC W Morrow
Oct 23, 1973·Psychopharmacologia·I G Karniol, E A Carlini
Nov 1, 1971·The Journal of Pharmacy and Pharmacology·R D SofiaH Barry
Jan 1, 1974·Psychopharmacologia·M FernandesR Hill
Jul 17, 1973·Psychopharmacologia·I Izquierdo, A G Nasello
Jan 1, 1973·Experientia·L E Hollister
Sep 1, 1973·Pharmacology, Biochemistry, and Behavior·D R Cherek, T Thompson

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Citations

Jul 28, 1976·Psychopharmacology·T U JärbeB G Henriksson
Nov 1, 1977·Pharmacology, Biochemistry, and Behavior·M R Leberer, S C Fowler
Oct 1, 1978·Pharmacology, Biochemistry, and Behavior·T U Järbe
Oct 1, 1980·Pharmacology, Biochemistry, and Behavior·T U Järbe
Oct 1, 1982·Pharmacology, Biochemistry, and Behavior·T U Järbe
Oct 4, 2011·The Journal of Pharmacology and Experimental Therapeutics·Brett C GinsburgLance R McMahon
Jun 17, 2016·The Journal of Pharmacology and Experimental Therapeutics·Robert A OwensAron H Lichtman

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