PMID: 108700Feb 28, 1979

Delta 9-tetrahydrocannabinol sensitization of the rat brain to direct cholinergic stimulation

Psychopharmacology
G E Duncan, R Dagirmanjian

Abstract

In an attempt to define the nature of the involvement of delta 9-tetrahydrocannabinol (THC) with central cholinergic neurotransmission, the effects of THC on direct cholinergic stimulation of the rat brain were investigated. THC, in doses of 3 mg/kg and 6 mg/kg, administered intraperitoneally (i.p.), potentiated the effects of carbachol injection into the lateral septal nucleus, as manifested by enhancement of the drinking response elicited by the septal carbachol injection and by potentiation of the tendency of this carbachol injection to induce abnormal motor responses. Although atropine (10 mg/kg, i.p.) completely blocked the carbachol induced drinking, the atropine did not completely block the drinking response when THC was given with carbachol. The results indicate an apparent sensitization, by THC, of a limbic cholinergic system.

References

Jan 1, 1974·Pharmacology·W G Drew, L L Miller
Sep 12, 1970·Nature·E L Abel
Feb 25, 1972·Science·T F Elsmore, G V Fletcher
May 23, 1970·Nature·C T Tart
Jan 15, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·G Singer, R B Montgomery
Jun 1, 1970·Physiology & Behavior·R A Levitt, R P Boley
Oct 28, 1966·Science·R A Levitt, A E FISHER
Apr 1, 1967·Experimental and Molecular Pathology·Z GoriM Pollera
Apr 1, 1962·The American Journal of Physiology·L STEIN, J SEIFTER

Citations

Feb 24, 2006·Behavioural Pharmacology·Lori M LievingOleg V Tcheremissine
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos

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