Delta 9-tetrahydrocannabinol suppresses vomiting behavior and Fos expression in both acute and delayed phases of cisplatin-induced emesis in the least shrew.

Behavioural Brain Research
Andrew P RayN A Darmani

Abstract

Cisplatin chemotherapy frequently causes severe vomiting in two temporally separated clusters of bouts dubbed the acute and delayed phases. Cannabinoids can inhibit the acute phase, albeit through a poorly understood mechanism. We examined the substrates of cannabinoid-mediated inhibition of both the emetic phases via immunolabeling for serotonin, Substance P, cannabinoid receptors 1 and 2 (CB(1), CB(2)), and the neuronal activation marker Fos in the least shrew (Cryptotis parva). Shrews were injected with cisplatin (10mg/kg i.p.), and one of vehicle, Delta(9)-THC, or both Delta(9)-THC and the CB(1) receptor antagonist SR141716A (2mg/kg i.p.), and monitored for vomiting. Delta(9)-THC-pretreatment caused concurrent decreases in the number of shrews expressing vomiting and Fos-immunoreactivity (Fos-IR), effects which were blocked by SR141716A-pretreatment. Acute phase vomiting induced Fos-IR in the solitary tract nucleus (NTS), dorsal motor nucleus of the vagus (DMNX), and area postrema (AP), whereas in the delayed phase Fos-IR was not induced in the AP at all, and was induced at lower levels in the other nuclei when compared to the acute phase. CB(1) receptor-IR in the NTS was dense, punctate labeling indicative of presynaptic e...Continue Reading

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Citations

Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Elizabeth J Rahn, Andrea G Hohmann
Nov 7, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Charles C HornMark I Friedman
Dec 24, 2010·British Journal of Pharmacology·Linda A ParkerCheryl L Limebeer
Aug 11, 2016·Frontiers in Pharmacology·Erin M Rock, Linda A Parker
Jun 16, 2017·The Journal of Physiological Sciences : JPS·Koichi AraseYoichi Ueta
Jun 21, 2020·The Journal of Pharmacology and Experimental Therapeutics·Lisa M WooldridgeBrian D Kangas
Oct 10, 2018·International Journal of Molecular Sciences·Sabrina CongediFranca Benini
Jun 9, 2018·Histochemistry and Cell Biology·Giorgia GaliazzoRoberto Chiocchetti
Apr 18, 2021·Autonomic Neuroscience : Basic & Clinical·Louiza BelkacemiNissar A Darmani
Feb 2, 2010·Pharmacology & Therapeutics·Angelo A Izzo, Keith A Sharkey

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