Delta-9-Tetrahydrocannabinol/Cannabidiol Oromucosal Spray (Sativex(®)): A Review in Multiple Sclerosis-Related Spasticity

Drugs
Gillian M Keating

Abstract

Delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray (THC/CBD, Sativex(®), nabiximols) is available in numerous countries worldwide for the treatment of multiple sclerosis (MS)-related moderate to severe spasticity in patients who have not responded adequately to other anti-spasticity medication and who demonstrate clinically significant improvement in spasticity-related symptoms during an initial trial of therapy. Twelve weeks' therapy with THC/CBD improved MS-related spasticity in patients with an inadequate response to other anti-spasticity agents who had undergone a successful initial trial of THC/CBD therapy, according to the results of a pivotal phase 3 trial. Improvements in spasticity were maintained in the longer term with THC/CBD with no evidence of dose tolerance, and results of real-world studies confirm the effectiveness of THC/CBD in everyday clinical practice. Improvements in health-related quality of life and activities of daily living were also seen with THC/CBD. THC/CBD is generally well tolerated; adverse effects such as dizziness may occur whilst the THC/CBD dosage is being optimized. THC/CBD has low abuse potential and a low risk of psychoactive effects. In conclusion, THC/CBD oromucosal sp...Continue Reading

References

Aug 1, 1995·Biological & Pharmaceutical Bulletin·K WatanabeH Yoshimura
Nov 8, 2006·Multiple Sclerosis : Clinical and Laboratory Research·D T WadeP Robson
Mar 16, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C CollinUNKNOWN Sativex Spasticity in MS Study Group
Aug 23, 2007·Chemistry & Biodiversity·Marilyn A Huestis
Feb 4, 2011·Clinical Pharmacology and Therapeutics·E L KarschnerM A Huestis
Mar 3, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A NovotnaUNKNOWN Sativex Spasticity Study Group
Jun 12, 2012·Expert Review of Pharmacoeconomics & Outcomes Research·John Slof, Adrien Gras
Nov 28, 2012·European Journal of Clinical Pharmacology·C G StottG W Guy
May 21, 2013·Acta Neurologica Scandinavica·J SvenssonP Nilsson
Dec 7, 2013·Expert Review of Neurotherapeutics·Ralf Gold, Celia Oreja-Guevara
Jan 8, 2014·The International Journal of Neuroscience·Jürgen KoehlerWalter Pöllmann
Sep 12, 2014·Acta Neurologica Scandinavica·M FreidelM Lang
Sep 26, 2014·PloS One·Rajarshi MazumderMichelle Cameron
Oct 16, 2014·Nature Reviews. Neuroscience·Raphael MechoulamAllyn C Howlett
Dec 23, 2014·Neurodegenerative Disease Management·Patrick Vermersch
Mar 17, 2015·Expert Review of Pharmacoeconomics & Outcomes Research·John SlofCarlos Vila
Aug 5, 2015·Journal of Neurology·G CogheE Cocco
Aug 15, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Vincenzo Di Marzo, Fabiana Piscitelli
Sep 27, 2015·Handbook of Experimental Pharmacology·Roger G Pertwee
Oct 18, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Laura FerrèFederica Esposito
Nov 28, 2015·Neurodegenerative Disease Management·Patrick Vermersch
Jan 12, 2016·Expert Review of Pharmacoeconomics & Outcomes Research·Adrien Gras, Julie Broughton
Mar 24, 2016·International Clinical Psychopharmacology·Lucio MarinelliCarlo Trompetto
Apr 4, 2016·Forensic Science International : Synergy·Francesca IndoratoNunziata Barbera
May 11, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·F PattiUNKNOWN SA.FE. study group
Aug 9, 2016·Acta Neurologica Scandinavica·A CarotenutoG Orefice
Oct 25, 2016·Journal of the Neurological Sciences·Giovanna SquintaniRoberto Erro
Dec 3, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G IllomeiM G Marrosu

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Citations

Apr 22, 2018·Neuropathology and Applied Neurobiology·D PanjaM Schubert
Aug 18, 2018·Nature Reviews. Drug Discovery·Vincenzo Di Marzo
Apr 14, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Gabriela DovrtelovaPetr Pavek
Aug 2, 2019·Stroke; a Journal of Cerebral Circulation·Sang-Ho ChoiAfonso C Silva
Dec 14, 2019·Nature Reviews. Neurology·Luigia CristinoVincenzo Di Marzo
Feb 15, 2020·Biomolecules·María Fernández-TraperoJavier Fernández-Ruiz
Jul 11, 2019·Journal of Clinical Medicine·Joshua D Brown, Almut G Winterstein
Aug 9, 2019·The Journal of Clinical Endocrinology and Metabolism·Joel Ehrenkranz, Michael A Levine
Jul 18, 2018·Cannabis and Cannabinoid Research·Jamie Corroon, Joy A Phillips
Jun 8, 2018·Neurochemical Research·Eric Murillo-RodríguezHenning Budde
Oct 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dvora NamdarHinanit Koltai
Feb 5, 2021·Complementary Therapies in Medicine·Yuval ZolotovMikhail Kogan
Apr 27, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Patrícia AlvesGeorgina Correia-da-Silva
Jul 3, 2021·Nutrients·Keely A ShawPhilip D Chilibeck
Jul 11, 2018·Journal of Medicinal Chemistry·Sonali S BharateRam A Vishwakarma
Jan 18, 2022·Leukemia & Lymphoma·Christopher M MelénBjörn Engelbrekt Wahlin

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