PMID: 3767287Sep 1, 1986Paper

delta-Aminolaevulinic acid dehydratase as an index of the presence and severity of lead poisoning in acute and chronic lead exposure

Annals of Clinical Biochemistry
Y Lolin, P O'Gorman

Abstract

The activity of delta-aminolaevulinic acid dehydratase (ALA-D; porphobilinogen synthase) was measured in whole blood from a group of workers with acute exposure to lead and with low blood lead levels, a group of workers with chronic lead exposure and high blood lead levels, and a group of people without undue environmental lead exposure. The activity of ALA-D was reduced significantly at low blood lead levels only if undue exposure to lead had occurred, and was thus a reflection of low level lead poisoning. In chronic lead exposure the enzyme was not invariably reactivated fully with dithiothreitol, indicating more severe enzyme poisoning. The one lead worker with symptomatic lead poisoning had the most marked enzyme suppression. Measurement of both ALA-D activity and blood lead levels was more useful than the measurement of blood lead levels alone in the diagnosis and assessment of the severity of lead poisoning.

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Citations

Dec 1, 1993·British Journal of Industrial Medicine·J DyerI F Pye
Nov 25, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J PerottoniT Emanuelli
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·W W KuW N Piper
Jan 1, 1995·European Journal of Clinical Investigation·G ChalevelakisS Raptis

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